SYNTHESIS OF 1,2,3,4-TETRAHYDRO-4-OXOTHIENO[3,2-D]PYRIMIDINE AND PERHYDROPYRIMIDINE DERIVATES FROM ALKYL DICYANOACETATES

被引：11
|
作者：
NEIDLEIN, R
SUI, Z
机构：
[1] Pharmazeutisch-Chemisches Institut, Universität Heidelberg, Heidelberg, D-6900
来源：
HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 03期
关键词：
D O I：
10.1002/hlca.19910740315
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nucleophilic addition of methyl 3-aminothiophene-2-carboxylate (2) as well as of beta-alanine ethyl ester (11) to one CN group of the salts 1 of alkyl dicyanoacetates, followed by cyclization, yielded 1,2,3,4-tetrahydro-4-oxothieno[3,2-d]pyridimine derivatives 6-10 (Scheme 1) and perhydropyrimidine derivatives 17-19 (Scheme 2), respectively.
引用
收藏
页码：579 / 584
页数：6
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