SYNTHESIS OF 1,2,3,4-TETRAHYDRO-4-OXOTHIENO[3,2-D]PYRIMIDINE AND PERHYDROPYRIMIDINE DERIVATES FROM ALKYL DICYANOACETATES

被引：11

作者：

NEIDLEIN, R

SUI, Z

机构：

[1] Pharmazeutisch-Chemisches Institut, Universität Heidelberg, Heidelberg, D-6900

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 03期

关键词：

D O I：

10.1002/hlca.19910740315

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleophilic addition of methyl 3-aminothiophene-2-carboxylate (2) as well as of beta-alanine ethyl ester (11) to one CN group of the salts 1 of alkyl dicyanoacetates, followed by cyclization, yielded 1,2,3,4-tetrahydro-4-oxothieno[3,2-d]pyridimine derivatives 6-10 (Scheme 1) and perhydropyrimidine derivatives 17-19 (Scheme 2), respectively.

引用

页码：579 / 584

页数：6

共 50 条

[1] Synthesis and reactions of biologically active 1,2,3,4-tetrahydro-4-oxo-2-thiobenzofuro[3,2-d]pyrimidine derivatives
Basavaraja, K. M.
Patil, V. M.
Agasimundin, Y. S.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 16 (02) : 159 - 162
[2] Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro [3,2-d] pyrimidines and their reactions
Basavaraja, K. M.
Patil, V. M.
Agasimundin, Y. S.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 17 (01) : 27 - 32
[3] DERIVATIVES OF PYRROLO(3,2-D)-PYRIMIDINE .2. SYNTHESIS OF 4-SUBSTITUTED DERIVATIVES OF PYRROLO(3,2-D) PYRIMIDINE AND STUDY OF THEIR BIOLOGICAL-ACTIVITY
BRITIKOVA, NE
NOVITSKY, KY
SHCHERBAKOVA, LI
PERSHIN, GN
KRAVCHENKO, AI
CHERNOV, VA
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (12): : 32 - 35
[4] THE SYNTHESIS OF 1,2,3,4-TETRAHYDRONAPHTHO[1,2-D]IMIDAZO[3,2-B]PYRIMIDINE AND 4,5-DIHYDRONAPHTHO[1,2-D]IMIDAZO[3,2-C]-1,2,4-TRIAZEPINE DERIVATIVES
PRIIMENKO, BA
ZHURNAL ORGANICHESKOI KHIMII, 1981, 17 (08): : 1787 - 1788
[5] SYNTHESIS OF PYRIDO [3',2'-4,5] THIENO [3,2-D] PYRIMIDINE-DERIVATIVES
SCHNELLER, SW
CLOUGH, FW
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1974, 11 (06) : 975 - 977
[6] Novel synthesis of a pyrrolo[3,2-d]pyrimidine.
Brown, CT
Welter, TR
Owczarczyk, B
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U136 - U136
[7] SYNTHESIS OF 2-PHENYLBENZOFURO-[3,2-D]PYRIMIDINE AND ITS DERIVATIVES
MULAGI, SM
SANGAPURE, SS
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1993, 32 (09): : 965 - 968
[8] SYNTHESIS OF SOME PYRIDO[2,3-D]PYRIMIDINE AND PYRIDO[3,2-D]PYRIMIDINE DERIVATIVES
SOLODUCHO, J
ARCHIV DER PHARMAZIE, 1990, 323 (08) : 513 - 515
[9] [1]BENZOTHIENOPYRIMIDINES .2. STUDY OF THE ELECTROPHILIC SUBSTITUTIONS OF [1]BENZOTHIENO[3,2-D]PYRIMIDINE AND [1]BENZOTHIENO[3,2-D]PYRIMIDIN-4-(3H)ONE
ELKASHEF, H
RAULT, S
SEVRICOURT, MCD
TOUZOT, P
ROBBA, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (07) : 1399 - 1404
[10] SYNTHESIS OF 1,2,3,4-TETRAHYDRO-3-OXOCARBAZOLE AND INDOLO[3,2-B]CARBAZOLE
HARLEYMASON, J
PAVRI, EH
JOURNAL OF THE CHEMICAL SOCIETY, 1963, (APR): : 2504 - &

← 1 2 3 4 5 →