ALTERATIONS IN NOCICEPTION AND BODY-TEMPERATURE AFTER INTRACISTERNAL ADMINISTRATION OF NEUROTENSIN, BETA-ENDORPHIN, OTHER ENDOGENOUS PEPTIDES, AND MORPHINE

The antinociceptive and hypothermic effects of intracisternal administration of 11 endogenous neuropeptides and morphine were evaluated in mice. Of the substances tested, only neurotensin (NT) and β-endorphin exerted significant antinociceptive and hypothermic effects; NT was the most potent antinociceptive agent via this route of administration. . Both NT and β-endorphin were, on a molar basis, considerably more potent antinociceptive agents than morphine, [Met]enkephalin, or [Leu]enkephalin. NT-induced analgesia and hypothermia both were significantly dose-dependent. Substance P was found to produce significant hyperalgesia and hyperthermia. Bombesin produced a significant hypothermic effect, whereas somatostatin and luteinizing hormone-releasing hormone (luliberin) produced hyperthermia. None of the other peptides studied [bradykinin, thyrotropin-releasing factor (thyroliberin), melanocyte-stimulating hormone release-inhibiting factor (melanostatin), somatostatin, [Met]enkephalin, and [Leu]enkephalin] produced any significant alterations in colonic temperature or response to a noxious stimulus with the doses tested. These data demonstrate that NT and β-endorphin, two endogenous brain peptides, are potent in inducing hypothermia and in producing an antinociceptive state.