Is Chlamydia pneumoniae consistent with atherosclerotic plaque rupture?

被引：1

作者：

Fazio, Giovanni ^{[1
]}

Sutera, Loredana ^{[1
]}

Zito, Rosanna ^{[1
]}

Cascio, Caterina ^{[1
]}

Briguglia, Daniele ^{[1
]}

Taormina, Susanna ^{[1
]}

Giammanco, Anna ^{[1
]}

Assennato, Pasquale ^{[1
]}

Novo, Salvatore ^{[1
]}

机构：

[1] Univ Palermo, Div Cardiol, Palermo, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2006年 / 7卷 / 12期

关键词：

Atherosclerosis; Chlamydia pneumoniae; Immunoglobulins; Myocardial infarction; Plaque rupture;

D O I：

10.1714/704.8068

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. The natural history of atherosclerosis has not clearly been elucidated yet. Some works reported that flogosis plays a role in plaque instability. Why does this inflammatory process start? We investigated the correlation between Chlamydia pneumoniae acute infection and plaque rupture. Methods. We compared blood concentrations of IgM anti-Chlamydia pneumoniae in patients affected by acute myocardial infarction (AMI) and in patients affected by stable angina. Results. Our results showed a minimal statistical difference, with a more positive value in patients with AMI. Subsequently, the group affected by AMI was divided into two subgroups with and without plaque rupture: the subgroup with plaque rupture showed a higher blood concentration of Chlamydia antibodies. This subgroup was also divided into two other subgroups according to blood white cell concentration: the subgroup with normal concentration of white blood cells showed the highest value of Chlamydia antibodies. Conclusions. Chlamydia pneumoniae could play an important role in atherosclerotic plaque instability.

引用

页码：809 / 814

页数：6

共 46 条

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