LABORATORY INDUCTION AND CLINICAL OCCURRENCE OF COMBINED CLINDAMYCIN AND ERYTHROMYCIN RESISTANCE IN CORYNEBACTERIUM ACNES

被引：98

作者：

CRAWFORD, WW

CRAWFORD, IP

STOUGHTON, RB

CORNELL, RC

机构：

[1] SCRIPPS CLIN & RES FDN, DIV DERMATOL, LA JOLLA, CA 92037 USA

[2] SCRIPPS CLIN & RES FDN, DEPT MICROBIOL, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1979年 / 72卷 / 04期

关键词：

D O I：

10.1111/1523-1747.ep12676385

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

C. [Propionibacterium] acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory. Similar strains were found among clinical isolates from patients using clindamycin or erythromycin topically in the treatment of acne vulgaris. Clindamycin resistance was never observed in the absence of resistance to macrolides or other lincosaminides. This resistance may result from an alteration of the 50S ribosomal subunit.

引用

页码：187 / 190

页数：4

共 10 条

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