Recent advances in the treatment of pediatric acute leukemia

被引：3

作者：

Kim, Hyery ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea

来源：

JOURNAL OF THE KOREAN MEDICAL ASSOCIATION | 2016年 / 59卷 / 09期

关键词：

Precursor cell lymphoblastic leukemia; Leukemia; myeloid; acute; Child; Therapeutics; Prognosis;

D O I：

10.5124/jkma.2016.59.9.690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past few decades, the survival rates of childhood acute leukemia have improved remarkably through treatment in risk-stratified prospective multicenter studies, and treatment protocols have evolved according to prognostic factors and treatment response. Recently, new molecular prognostic factors have been discovered through leukemic genome studies, and new subtypes with independent gene expression profiles have also been found. Furthermore, candidate mutations for target agents are being discovered, which will broaden therapeutic options for patients with poor prognostic factors. New drugs are currently being evaluated in clinical trials, and immunotherapy is now attracting interest in the treatment of recurrent or refractory disease in pediatric acute leukemia.

引用

页码：690 / 697

页数：8

共 25 条

[11] Frequency and Clinical Characteristics of Intrachromosomal Amplification of Chromosome 21 in Korean Childhood B-lineage Acute Lymphoblastic Leukemia [J].

Kim, Jieun ;

Lyu, Chuhl Joo ;

Shin, Saeam ;

Lee, Seung-Tae ;

Choi, Jong Rak .

ANNALS OF LABORATORY MEDICINE, 2016, 36 (05) :475-480

[12] Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232 [J].

Larsen, Eric C. ;

Devidas, Meenakshi ;

Chen, Si ;

Salzer, Wanda L. ;

Raetz, Elizabeth A. ;

Loh, Mignon L. ;

Mattano, Leonard A., Jr. ;

Cole, Catherine ;

Eicher, Alisa ;

Haugan, Maureen ;

Sorenson, Mark ;

Heerema, Nyla A. ;

Carroll, Andrew A. ;

Gastier-Foster, Julie M. ;

Borowitz, Michael J. ;

Wood, Brent L. ;

Willman, Cheryl L. ;

Winick, Naomi J. ;

Hunger, Stephen P. ;

Carroll, William L. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (20) :2380-U129

[13]

Lee JW, 2016, PEDIAT BLOOD CANC

[14] Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group [J].

Matloub, Yousif ;

Lindemulder, Susan ;

Gaynon, Paul S. ;

Sather, Harland ;

La, Mei ;

Broxson, Emmett ;

Yanofsky, Rochelle ;

Hutchinson, Raymond ;

Heerema, Nyla A. ;

Nachman, James ;

Blake, Marilyn ;

Wells, Linda M. ;

Sorrell, April D. ;

Masterson, Margaret ;

Kelleher, John F. ;

Stork, Linda C. .

BLOOD, 2006, 108 (04) :1165-1173

[15] Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia [J].

Maude, Shannon L. ;

Frey, Noelle ;

Shaw, Pamela A. ;

Aplenc, Richard ;

Barrett, David M. ;

Bunin, Nancy J. ;

Chew, Anne ;

Gonzalez, Vanessa E. ;

Zheng, Zhaohui ;

Lacey, Simon F. ;

Mahnke, Yolanda D. ;

Melenhorst, Jan J. ;

Rheingold, Susan R. ;

Shen, Angela ;

Teachey, David T. ;

Levine, Bruce L. ;

June, Carl H. ;

Porter, David L. ;

Grupp, Stephan A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (16) :1507-1517

[16] Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia. [J].

Mullighan, Charles G. ;

Su, Xiaoping ;

Zhang, Jinghui ;

Radtke, Ina ;

Phillips, Letha A. A. ;

Miller, Christopher B. ;

Ma, Jing ;

Liu, Wei ;

Cheng, Cheng ;

Schulman, Brenda A. ;

Harvey, Richard C. ;

Chen, I-Ming ;

Clifford, Robert J. ;

Carroll, William L. ;

Reaman, Gregory ;

Bowman, W. Paul ;

Devidas, Meenakshi ;

Gerhard, Daniela S. ;

Yang, Wenjian ;

Relling, Mary V. ;

Shurtleff, Sheila A. ;

Campana, Dario ;

Borowitz, Michael J. ;

Pui, Ching-Hon ;

Smith, Malcolm ;

Hunger, Stephen P. ;

Willman, Cheryl L. ;

Downing, James R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (05) :470-480

[17] Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia [J].

Patel, Jay P. ;

Goenen, Mithat ;

Figueroa, Maria E. ;

Fernandez, Hugo ;

Sun, Zhuoxin ;

Racevskis, Janis ;

Van Vlierberghe, Pieter ;

Dolgalev, Igor ;

Thomas, Sabrena ;

Aminova, Olga ;

Huberman, Kety ;

Cheng, Janice ;

Viale, Agnes ;

Socci, Nicholas D. ;

Heguy, Adriana ;

Cherry, Athena ;

Vance, Gail ;

Higgins, Rodney R. ;

Ketterling, Rhett P. ;

Gallagher, Robert E. ;

Litzow, Mark ;

van den Brink, Marcel R. M. ;

Lazarus, Hillard M. ;

Rowe, Jacob M. ;

Luger, Selina ;

Ferrando, Adolfo ;

Paietta, Elisabeth ;

Tallman, Martin S. ;

Melnick, Ari ;

Abdel-Wahab, Omar ;

Levine, Ross L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (12) :1079-1089

[18] Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region [J].

Pui, CH ;

Gaynon, PS ;

Boyett, JM ;

Chessells, JM ;

Baruchel, A ;

Kamps, W ;

Silverman, LB ;

Biondi, A ;

Harms, DO ;

Vilmer, E ;

Schrappe, M ;

Camitta, B .

LANCET, 2002, 359 (9321) :1909-1915

[19] Acute lymphoblastic leukaemia [J].

Pui, Ching-Hon ;

Robison, Leslie L. ;

Look, A. Thomas .

LANCET, 2008, 371 (9617) :1030-1043

[20]

Pui Ching-Hon, 2004, Hematology Am Soc Hematol Educ Program, P118

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