INHIBITION OF PHENACETIN- AND ACETANILIDE-INDUCED METHEMOGLOBINEMIA IN RAT BY CARBOXYLESTERASE INHIBITOR BIS-[P-NITROPHENYL] PHOSPHATE

被引：80

作者：

HEYMANN, E

KRISCH, K

BUCH, H

BUZELLO, W

机构：

[1] Physiologisch-Chemisches Institut der Justus-Liebig-Universität

[2] Institut für Pharmakologie

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 04期

关键词：

D O I：

10.1016/0006-2952(69)90050-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The formation of methemoglobin caused by phenacetin and acetanilide in rats is inhibited by simultaneous treatment with if Bis-[p-nitrophenyl] phosphate (BNPP), a new carboxylesterase inhibitor, while the methemoglobinemia after p-phenetidine is not influenced by BNPP. The duration of BNPP action on phenacetin-induced methemoglobinemia and the spontaneous return of liver esterase activity after a single dose of BNPP have been studied. The enzymatic hydrolysis of the amide bond of phenacetin by rat liver, in vivo and in vitro, is inhibited considerably less by BNPP than the hydrolysis of acetanilide, monoethylglycine-2,6-xylidide and methyl butyrate, and another amidase may be involved in the deacetylation of phenacetin by rat liver. © 1969.

引用

页码：801 / &

共 20 条

[1]

BAADER H, 1961, ARCH EXP PATHOL PH, V241, P317

[2]

BEISENHERZ G, 1953, Z NATURFORSCH B, V8, P555

[3]

BENOHR HC, 1966, ARCH EXP PATHOL PH, V255, P163

[4] DEACETYLATION OF PHENACETIN BY LIVER ESTERASE [J].