GLYOXALASE INHIBITORS AS POTENTIAL ANTICANCER AGENTS

A study of a series of S-alkylglutathiones as inhibitors of the enzyme, glyoxalase I, revealed that a non-polar region exists on the enzyme which plays an important role in the formation of an enzyme-inhibitor complex. The amount of inhibition of glyoxalase increases as the alkyl chain is lengthened from methyl to n-octyl. By taking advantage of the non-polar region of the enzyme, compounds have been prepared which are 435 times more active than the previously reported S-methylglutathione. © 1969.