SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN

被引：0
|
作者：
OHWADA, J [1 ]
UMEDA, I [1 ]
ONTSUKA, H [1 ]
AOKI, Y [1 ]
SHIMMA, N [1 ]
机构：
[1] NIPPON ROCHE RES CTR, KAMAKURA, KANAGAWA 247, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 08期
关键词：
AZOXYBACILIN; ANTIFUNGAL; SYNTHESIS; STRUCTURE-ACTIVITY RELATIONSHIP;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O(t)Bu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.
引用
收藏
页码：1703 / 1705
页数：3
相关论文
共 50 条
  • [31] Synthesis and Structure-Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives
    Yang, Yazhou
    Zhou, Yujie
    Jiang, Qiaoju
    Tan, Yi
    Wu, Wenbin
    Han, Ke
    Zhu, Rui
    Zheng, Shaojun
    MOLECULES, 2023, 28 (06):
  • [32] PREDICTION OF ENVIRONMENTAL TOXICITY BASED ON STRUCTURE-ACTIVITY-RELATIONSHIPS USING MECHANISTIC INFORMATION
    HERMENS, J
    SCIENCE OF THE TOTAL ENVIRONMENT, 1995, 171 (1-3) : 235 - 242
  • [33] Synthesis and in vitro antifungal activity of novel tetralin compounds
    Yao Bin
    Zhou You-Jun
    Zhu Ju
    Lu Jia-Guo
    Jiang Yuan-Ying
    Chen Jun
    Cao Yong-Bing
    Jiang Qing-Feng
    Zheng Can-Hui
    ACTA CHIMICA SINICA, 2007, 65 (03) : 257 - 264
  • [34] STRUCTURE-ACTIVITY-RELATIONSHIPS IN PLATELET-ACTIVATING-FACTOR (PAF) .5. SYNTHESIS AND INVITRO ANTAGONISTIC ACTIVITIES OF KETOPHOSPHONATES
    FURNODEWINTER, A
    BROQUET, C
    HAELTERS, JP
    MASSICOT, F
    STURTZ, G
    GODFROID, JJ
    JOURNAL OF LIPID MEDIATORS, 1991, 3 (03): : 289 - 300
  • [35] Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei
    Seufert, Florian
    Kuhn, Maximilian
    Hein, Michael
    Weiwad, Matthias
    Vivoli, Mirella
    Norville, Isobel H.
    Sarkar-Tyson, Mitali
    Marshall, Laura E.
    Schweimer, Kristian
    Bruhn, Heike
    Roesch, Paul
    Harmer, Nicholas J.
    Sotriffer, Christoph A.
    Holzgrabe, Ulrike
    BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (21) : 5134 - 5147
  • [36] GLYCYRRHETINIC ACID-DERIVATIVES AS POTENT INHIBITORS OF NA+, K+-ATPASE - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS
    TERASAWA, T
    OKADA, T
    HARA, T
    ITOH, K
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (04) : 345 - 351
  • [37] Design, synthesis and antifungal activity of novel furancarboxamide derivatives
    Wen, Fang
    Jin, Hong
    Tao, Ke
    Hou, Taiping
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 120 : 244 - 251
  • [38] Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation
    Dimitrakis, Spyridon
    Gavriil, Efthymios-Spyridon
    Pousias, Athanasios
    Lougiakis, Nikolaos
    Marakos, Panagiotis
    Pouli, Nicole
    Gioti, Katerina
    Tenta, Roxane
    MOLECULES, 2022, 27 (01):
  • [39] Synthesis of novel substituted tetrazoles having antifungal activity
    Upadhayaya, RS
    Jain, S
    Sinha, N
    Kishore, N
    Chandra, R
    Arora, SK
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (07) : 579 - 592
  • [40] Synthesis and antifungal activity of two novel spermidine analogues
    Mackintosh, CA
    Slater, LA
    McClintock, CA
    Walters, DR
    Havis, ND
    Robins, DJ
    FEMS MICROBIOLOGY LETTERS, 1997, 148 (01) : 21 - 25
12345