SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN

被引：0

作者：

OHWADA, J ^{[1
]}

UMEDA, I ^{[1
]}

ONTSUKA, H ^{[1
]}

AOKI, Y ^{[1
]}

SHIMMA, N ^{[1
]}

机构：

[1] NIPPON ROCHE RES CTR, KAMAKURA, KANAGAWA 247, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 08期

关键词：

AZOXYBACILIN; ANTIFUNGAL; SYNTHESIS; STRUCTURE-ACTIVITY RELATIONSHIP;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O(t)Bu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.

引用

页码：1703 / 1705

页数：3

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