SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A NOVEL ANTIFUNGAL AGENT, AZOXYBACILIN

被引：0
|
作者：
OHWADA, J [1 ]
UMEDA, I [1 ]
ONTSUKA, H [1 ]
AOKI, Y [1 ]
SHIMMA, N [1 ]
机构：
[1] NIPPON ROCHE RES CTR, KAMAKURA, KANAGAWA 247, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 08期
关键词：
AZOXYBACILIN; ANTIFUNGAL; SYNTHESIS; STRUCTURE-ACTIVITY RELATIONSHIP;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new antifungal substance, azoxybacilin (an unusual amino acid with an azoxy moiety) and its derivatives have been synthesized from Boc-L-Asp-O(t)Bu utilizing the Moss procedure for the preparation of the azoxy moiety. The ester derivative, Ro 09-1824, showed more potent antifungal activity and a broader antifungal spectrum than azoxybacilin did.
引用
收藏
页码：1703 / 1705
页数：3
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