ISLET-CELL GROWTH AND THE GROWTH-FACTORS INVOLVED

被引：73
作者：
BONNERWEIR, S
SMITH, FE
机构：
[1] Joslin Diabetes Center, Brigham and Women's Hospital Harvard Medical School, Boston, MA 02215
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/1043-2760(94)90003-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Throughout development, growth and aging, the mass of the pancreatic islets, in particular the insulin-producing beta cell, increases to meet the functional demand and maintain euglycemia. Islet growth occurs by two pathways: (a) the expansion by replication of preexisting beta cells and (b) the formation of new islets (neogenesis) by proliferation and subsequent differentiation of pancreatic ductal epithelium. Some of the factors involved in these pathways of islet growth have been defined.
引用
收藏
页码：60 / 64
页数：5
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