CHROMOSOME-ABERRATIONS IN NUCLEAR-POWER-PLANT WORKERS - THE INFLUENCE OF DOSE ACCUMULATION AND LYMPHOCYTE LIFETIME

Chromosome analyses were performed in blood lymphocytes of 22 nuclear power plant workers with a mean accumulated radiation dose of 390 mSv (270-530 mSv). Nineteen workers had received 300 mSv 4-16 years prior to sampling. The frequency of dicentrics and ring chromosomes (1.75 x 10(-3)) was significantly elevated as compared to a control group (0.58 x 10(-3)). Based on the initial slope of an in vitro Co-60 gamma-ray curve, a biological dose estimate of only 110 mSv was derived. This can be interpreted in terms of an ''equivalent-acute'' dose at the time of blood sampling which can be derived by weighting annual doses during working periods of 12-30 years for a mean life-time m of lymphocytes. The annual doses were additionally weighted for a uniform distribution during a whole year. Using m = 10 years, a mean ''equivalent-acute'' dose of 90 mSv (64-157 mSv) is obtained, which compares more closely to the biologically estimated dose than 20 mSv (7-71 mSv) based on m = 4.3 years.