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THROMBOXANE RECEPTOR STIMULATION INHIBITS ADENYLATE-CYCLASE AND REDUCES CYCLIC AMP-MEDIATED INHIBITION OF ADP-EVOKED RESPONSES IN FURA-2-LOADED HUMAN PLATELETS
被引：14
作者：
SAGE, SO
HEEMSKERK, JWM
机构：
[1] UNIV LIMBURG,DEPT BIOCHEM,POB 616,6200 MD MAASTRICHT,NETHERLANDS
[2] UNIV CAMBRIDGE,PHYSIOL LAB,CAMBRIDGE CB2 3EG,ENGLAND
关键词：
PLATELET;
THROMBOXANE-A(2);
ADENYLATE CYCLASE;
CALCIUM;
MANGANESE;
FLUORESCENT INDICATOR;
D O I：
10.1016/0014-5793(92)80056-M
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
Stimulation of human platelets with the thromboxane A2 analogue, U46619, after treatment with prostaglandin E1 or forskolin, reduced the inhibition of ADP-evoked Mn2+ influx and the release of Ca2+ from intracellular stores. U46619 decreased the elevated concentration of 3',5'-cyclic AMP in platelets that were pretreated with prostaglandin E1. These results suggest that occupation of prostaglandin H-2/thromboxane A2 receptors, like those for other agonists, inhibits adenylate cyclase activity, which can contribute to the promotion of platelet activation.
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页码：199 / 202
页数：4
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