A PROSPECTIVE-STUDY OF THE CATHETER HUB AS THE PORTAL OF ENTRY FOR MICROORGANISMS CAUSING CATHETER-RELATED SEPSIS IN NEONATES

被引：143
作者：
SALZMAN, MB
ISENBERG, HD
SHAPIRO, JF
LIPSITZ, PJ
RUBIN, LG
机构：
[1] LONG ISL JEWISH MED CTR,SCHNEIDER CHILDRENS HOSP,DEPT PEDIAT,DIV INFECT DIS,NEW HYDE PK,NY 11042
[2] LONG ISL JEWISH MED CTR,SCHNEIDER CHILDRENS HOSP,DIV NEONATOL,NEW HYDE PK,NY 11042
[3] ALBERT EINSTEIN COLL MED,LONG ISL JEWISH MED CTR,DEPT PATHOL,DIV MICROBIOL,NEW HYDE PK,NY
来源：
JOURNAL OF INFECTIOUS DISEASES | 1993年 / 167卷 / 02期
关键词：
D O I：
10.1093/infdis/167.2.487
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The hypothesis that catheter-related sepsis (CRS) may be preceded by contamination of the catheter hub was tested in neonates with central venous catheters. Cultures of the catheter hub were obtained three times per week. One hundred thirteen catheters were placed in 88 patients. Of 35 episodes of sepsis, 28 were catheter-related. for a catheter sepsis rate of 1.03/100 catheter-days. CRS occurred in 26 (23%) of 113 catheters. In 10 of 28 episodes. the infecting microorganism was cultured from the hub before its culture from blood obtained at the time of clinical sepsis. In an additional 5 cases. a culture of the catheter hub at the time of clinical sepsis yielded the same isolate as the blood culture. Thus, 54% of episodes of CRS were preceded by or coincided with contamination of the hub. The catheter hub may be a major portal of entry for microorganisms causing sepsis in a neonatal intensive care unit.
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页码：487 / 490
页数：4
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