ACTION OF INTERLEUKIN-2 AND INTERLEUKIN-4 ON CRF MESSENGER-RNA IN THE HYPOTHALAMUS AND POMC MESSENGER-RNA IN THE ANTERIOR-PITUITARY

被引：27

作者：

HARBUZ, MS ^{[1
]}

STEPHANOU, A ^{[1
]}

KNIGHT, RA ^{[1
]}

CHOVERGONZALEZ, AJ ^{[1
]}

LIGHTMAN, SL ^{[1
]}

机构：

[1] NATL HEART & LUNG INST,DEPT CYST FIBROSIS,LONDON SW3 6LR,ENGLAND

来源：

BRAIN BEHAVIOR AND IMMUNITY | 1992年 / 6卷 / 03期

关键词：

D O I：

10.1016/0889-1591(92)90044-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have used the technique of in situ hybridization histochemistry to determine corticotropin-releasing factor (CRF) mRNA in the hypothalamic paraventricular nucleus (PVN) and proopiomelanocortin (POMC) mRNA in the anterior pituitary of rats given a single ip injection of either interleukin (IL)-2 or IL-4. IL-2 increased POMC mRNA in the anterior pituitary in a dose-dependent manner. The effect was apparent both at 4 and 24 h after injection. No effect of IL-2 on CRF mRNA in the PVN was detected in these animals, suggesting that the increase in POMC mRNA was not driven by an increase in CRF. IL-4 was without effect at the hypothalamic level although this cytokine did result in a decrease in POMC mRNA in the anterior pituitary. © 1992.

引用

页码：214 / 222

页数：9

共 42 条

[1] THE IMMUNE-HYPOTHALAMIC-PITUITARY-ADRENAL AXIS [J].

BATEMAN, A ;

SINGH, A ;

KRAL, T ;

SOLOMON, S .

ENDOCRINE REVIEWS, 1989, 10 (01) :92-112

[2] IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES [J].

BESEDOVSKY, H ;

DELREY, A ;

SORKIN, E ;

DINARELLO, CA .

SCIENCE, 1986, 233 (4764) :652-654

[3] CLEARANCE RATES AND SYSTEMIC EFFECTS OF INTRAVENOUSLY ADMINISTERED INTERLEUKIN-2 (IL-2) CONTAINING PREPARATIONS IN HUMAN-SUBJECTS [J].

BINDON, C ;

CZERNIECKI, M ;

RUELL, P ;

EDWARDS, A ;

MCCARTHY, WH ;

HARRIS, R ;

HERSEY, P .

BRITISH JOURNAL OF CANCER, 1983, 47 (01) :123-133

[4] INTERLEUKIN-2 MODIFIES THE BIOELECTRIC ACTIVITY OF SOME NEUROSECRETORY NUCLEI IN THE RAT HYPOTHALAMUS [J].

BINDONI, M ;

PERCIAVALLE, V ;

BERRETTA, S ;

BELLUARDO, N ;

DIAMANTSTEIN, T .

BRAIN RESEARCH, 1988, 462 (01) :10-14

[5] DEXAMETHASONE INHIBITS HUMAN INTERLEUKIN-2 BUT NOT INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION INVITRO AT THE LEVEL OF NUCLEAR TRANSCRIPTION [J].

BOUMPAS, DT ;

ANASTASSIOU, ED ;

OLDER, SA ;

TSOKOS, GC ;

NELSON, DL ;

BALOW, JE .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (05) :1739-1747

[6]

BROWN SL, 1987, J IMMUNOL, V139, P3181

[7]

BUZZETTI R, 1988, J ENDOCRINOL, V119, P95

[8]

DELPRETE G, 1988, J IMMUNOL, V140, P4193

[9]

DELREY A, 1987, ANN NY ACAD SCI, V496, P85

[10] THE NEURO-ENDOCRINE EFFECTS OF INTERLEUKIN-2 TREATMENT [J].

DENICOFF, KD ;

DURKIN, TM ;

LOTZE, MT ;

QUINLAN, PE ;

DAVIS, CL ;

LISTWAK, SJ ;

ROSENBERG, SA ;

RUBINOW, DR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 69 (02) :402-410

← 1 2 3 4 5 →