MODULATION OF ACETYLCHOLINE-RELEASE FROM THE MYENTERIC PLEXUS OF GUINEA-PIG ILEUM BY 5-LIPOXYGENASE METABOLITES OF ARACHIDONIC-ACID

被引：9
|
作者：
YOSHIKAWA, S
FUKUNAGA, Y
TAKEUCHI, T
NISHIO, H
HATA, F
机构：
[1] Department of Veterinary Pharmacology, Osaka Prefectural University, Sakai
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 239卷 / 1-3期
关键词：
5-LIPOXYGENASE; ACETYLCHOLINE RELEASE; LEUKOTRIENE-D(4); MYENTERIC PLEXUS;
D O I：
10.1016/0014-2999(93)91008-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eicosatetraenoic acid, an inhibitor of 5- and 12-lipoxygenase, and AA861, a selective inhibitor of 5-lipoxygenase, dose dependently inhibited acetylcholine release from the myenteric plexus of guinea-pig ileum induced by electrical field stimulation. Metabolites of arachidonic acid produced by the 5-lipoxygenase pathway, such as 5-hydroxyeicosatetraenoic acid (5-HETE), leukotriene C4, D4 and E4, reversed the inhibitory effect of AA861. Among them, leukotriene D4 was the most potent, having an EC50 value of about 3 nM. The present study shows for the first time that 5-lipoxygenase metabolites may have a modulatory effect on acetylcholine release in the myenteric plexus of guinea-pig ileum.
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页码：261 / 264
页数：4
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