PROGRAMMED DEATH OF T-CELLS IN HIV-1 INFECTION

被引：900
作者：
MEYAARD, L
OTTO, SA
JONKER, RR
MIJNSTER, MJ
KEET, RPM
MIEDEMA, F
机构：
[1] NETHERLANDS RED CROSS, BLOOD TRANSFUS SERV,CENT LAB, DEPT CLIN VIROIMMUNOL,PLESMANLAAN 125, AMSTERDAM, NETHERLANDS
[2] UNIV AMSTERDAM, EXPTL & CLIN IMMUNOL LAB, 1066 CX AMSTERDAM, NETHERLANDS
[3] TNO, INST APPL RADIOBIOL & IMMUNOL, DEPT MOLEC PATHOL, 2280 HV RIJSWIJK, NETHERLANDS
[4] NETHERLANDS INST BRAIN RES, 1095 KJ AMSTERDAM, NETHERLANDS
[5] MUNICIPAL HLTH SERV, DEPT INFECT DIS, AMSTERDAM, NETHERLANDS
来源：
SCIENCE | 1992年 / 257卷 / 5067期
关键词：
D O I：
10.1126/science.1352911
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.
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收藏
页码：217 / 219
页数：3
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