AGE-RELATED-CHANGES IN TRANSMITTER GLUTAMATE AND NMDA RECEPTOR CHANNELS IN THE BRAIN OF SENESCENCE-ACCELERATED MOUSE

被引：57

作者：

KITAMURA, Y ^{[1
]}

ZHAO, XH ^{[1
]}

OHNUKI, T ^{[1
]}

TAKEI, M ^{[1
]}

NOMURA, Y ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 137卷 / 02期

关键词：

GLUTAMATERGIC NEURON; NMDA RECEPTOR CHANNEL; LEARNING AND MEMORY; AGING; HIPPOCAMPUS; CEREBRAL CORTEX; SENESCENCE-ACCELERATED MOUSE;

D O I：

10.1016/0304-3940(92)90396-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The senescence-accelerated mouse (SAM-P/8) is known as a murine model of aging and memory dysfunction. In the hippocampus and cerebral cortex of P/8, the contents of glutamic acid and glutamine were significantly higher than those of normal strain R/1 during 2 and 14 months. High K+-evoked endogenous glutamic acid release from the slices of P/8 was increased in comparison with R/1 at 9 and 11 months. In addition, the B(max) of [H-3]dizocilpine (MK-801, channel blocker for N-methyl-D-aspartic acid receptor/channel) binding in the cerebral cortex was age-dependently decreased in P/8 but not in R/1. These results suggest that synaptic dysfunctions in the glutamatergic system occur in the CNS of SAM-P/8.

引用

页码：169 / 172

页数：4

共 21 条

[1] PERIODIC ACID-SCHIFF (PAS)-POSITIVE, ANTIGRANULOCYTES STRUCTURES INCREASE IN THE BRAIN OF SENESCENCE ACCELERATED MOUSE (SAM) [J].

AKIYAMA, H ;

KAMEYAMA, M ;

AKIGUCHI, I ;

SUGIYAMA, H ;

KAWAMATA, T ;

FUKUYAMA, H ;

KIMURA, H ;

MATSUSHITA, M ;

TAKEDA, T .

ACTA NEUROPATHOLOGICA, 1986, 72 (02) :124-129

[2] BIOCHEMICAL-EVIDENCE OF SELECTIVE NERVE-CELL CHANGES IN THE NORMAL AGING HUMAN AND RAT-BRAIN [J].

ALLEN, SJ ;

BENTON, JS ;

GOODHARDT, MJ ;

HAAN, EA ;

SIMS, NR ;

SMITH, CCT ;

SPILLANE, JA ;

BOWEN, DM ;

DAVISON, AN .

JOURNAL OF NEUROCHEMISTRY, 1983, 41 (01) :256-265

[3]

ENDO T, 1987, JPN J LEGAL MED, V41, P308

[4] ENHANCEMENT OF TRANSMITTER RELEASE ACCOMPANYING WITH LONG-TERM POTENTIATION IN SYNAPSES BETWEEN MOSSY FIBERS AND CA3 NEURONS IN HIPPOCAMPUS [J].

HIRATA, K ;

SAWADA, S ;

YAMAMOTO, C .

NEUROSCIENCE LETTERS, 1991, 123 (01) :73-76

[5] STUDIES ON NEUROTRANSMITTER MARKERS AND NEURONAL CELL-DENSITY IN THE CEREBELLAR SYSTEM IN OLIVOPONTOCEREBELLAR ATROPHY AND CORTICAL CEREBELLAR ATROPHY [J].

KANAZAWA, I ;

KWAK, S ;

SASAKI, H ;

MIZUSAWA, H ;

MURAMOTO, O ;

YOSHIZAWA, K ;

NUKINA, N ;

KITAMURA, K ;

KURISAKI, H ;

SUGITA, K .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1985, 71 (2-3) :193-208

[6] LIGAND-BINDING CHARACTERISTICS OF [H-3] QNB, [H-3] PRAZOSIN, [H-3] RAUWOLSCINE, [H-3] TCP AND [H-3] NITRENDIPINE TO CEREBRAL CORTICAL AND HIPPOCAMPAL MEMBRANES OF SENESCENCE ACCELERATED MOUSE [J].

KITAMURA, Y ;

ZHAO, XH ;

OHNUKI, T ;

NOMURA, Y .

NEUROSCIENCE LETTERS, 1989, 106 (03) :334-338

[7] AGE-RELATED-CHANGES IN LEARNING AND MEMORY IN THE SENESCENCE-ACCELERATED MOUSE (SAM) [J].

MIYAMOTO, M ;

KIYOTA, Y ;

YAMAZAKI, N ;

NAGAOKA, A ;

MATSUO, T ;

NAGAWA, Y ;

TAKEDA, T .

PHYSIOLOGY & BEHAVIOR, 1986, 38 (03) :399-406

[8]

Nicklas W J, 1984, Adv Neurol, V41, P245

[9]

NOMURA Y, 1991, NMDA RECEPTOR RELATED AGENTS : BIOCHEMISTRY, PHARMACOLOGY AND BEHAVIOR, P287

[10] BEHAVIORAL-CHARACTERISTICS OF THE SAM-P-8 STRAIN IN SIDMAN ACTIVE-AVOIDANCE TASK [J].

OHTA, A ;

HIRANO, T ;

YAGI, H ;

TANAKA, S ;

HOSOKAWA, M ;

TAKEDA, T .

BRAIN RESEARCH, 1989, 498 (01) :195-198

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