TRANSFORMING GROWTH FACTOR-ALPHA EXPRESSION IN NORMAL GASTRIC-MUCOSA, INTESTINAL METAPLASIA, DYSPLASIA AND GASTRIC-CARCINOMA - AN IMMUNOHISTOCHEMICAL STUDY

被引：32
作者：
NASIM, MM
THOMAS, DM
ALISON, MR
FILIPE, MI
机构：
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOPATHOL,DU CANE RD,LONDON W12 0HS,ENGLAND
[2] UNIV MED & DENT SCH GUYS EL ST THOMAS HOSP,LONDON,ENGLAND
来源：
HISTOPATHOLOGY | 1992年 / 20卷 / 04期
关键词：
TGF-ALPHA; STOMACH; INTESTINAL METAPLASIA; DYSPLASIA; CARCINOMA;
D O I：
10.1111/j.1365-2559.1992.tb00991.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Using a monoclonal antibody (GF10) and a standard immunohistochemical technique, immuno-expression of transforming growth factor-alpha (TGF-alpha) was found consistently within the differentiated compartment of normal adult human gastric mucosa. In 70% of mucosal samples exhibiting intestinal metaplasia there was more or less uniform TGF-alpha-immunoreactivity throughout the intestinalized mucosa. Similarly, 60% of cases of dysplasia and 60% of gastric carcinomas showed strong immunoreactivity in most of the cells. However, whereas 93% of intestinal-type cancers showed strong immunoreactivity only 30% of the diffuse type were stained and then only weakly. Transforming growth factor alpha-expression is thus a fairly regular feature of several types of differentiated gastric epithelia (normal, metaplastic, dysplastic and intestinal-type carcinoma), while its relative absence may be a factor in the histogenesis of the diffuse type of gastric carcinoma.
引用
收藏
页码：339 / 343
页数：5
相关论文
共 37 条
[1]   CELL-CELL ADHESION MEDIATED BY BINDING OF MEMBRANE-ANCHORED TRANSFORMING GROWTH FACTOR-ALPHA TO EPIDERMAL GROWTH-FACTOR RECEPTORS PROMOTES CELL-PROLIFERATION [J].
ANKLESARIA, P ;
TEIXIDO, J ;
LAIHO, M ;
PIERCE, JH ;
GREENBERGER, JS ;
MASSAGUE, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3289-3293
[2]   EXPRESSION OF THE TRANSFORMING GROWTH FACTOR-ALPHA EPIDERMAL GROWTH-FACTOR RECEPTOR PATHWAY IN NORMAL HUMAN-BREAST EPITHELIAL-CELLS [J].
BATES, SE ;
VALVERIUS, EM ;
ENNIS, BW ;
BRONZERT, DA ;
SHERIDAN, JP ;
STAMPFER, MR ;
MENDELSOHN, J ;
LIPPMAN, ME ;
DICKSON, RB .
ENDOCRINOLOGY, 1990, 126 (01) :596-607
[3]  
BENNETT C, 1989, CANCER RES, V49, P2104
[4]  
Campbell I D, 1989, Prog Growth Factor Res, V1, P13, DOI 10.1016/0955-2235(89)90038-0
[5]   TRANSFORMING GROWTH FACTOR-ALPHA AND EPIDERMAL GROWTH-FACTOR LEVELS IN NORMAL HUMAN GASTROINTESTINAL MUCOSA [J].
CARTLIDGE, SA ;
ELDER, JB .
BRITISH JOURNAL OF CANCER, 1989, 60 (05) :657-660
[6]   PRODUCTION AND AUTOINDUCTION OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN KERATINOCYTES [J].
COFFEY, RJ ;
DERYNCK, R ;
WILCOX, JN ;
BRINGMAN, TS ;
GOUSTIN, AS ;
MOSES, HL ;
PITTELKOW, MR .
NATURE, 1987, 328 (6133) :817-820
[7]  
DELARCO JE, 1978, P NATL ACAD SCI USA, V75, P4001
[8]   HUMAN TRANSFORMING GROWTH FACTOR-ALPHA - PRECURSOR STRUCTURE AND EXPRESSION IN ESCHERICHIA-COLI [J].
DERYNCK, R ;
ROBERTS, AB ;
WINKLER, ME ;
CHEN, EY ;
GOEDDEL, DV .
CELL, 1984, 38 (01) :287-297
[9]  
DERYNCK R, 1987, CANCER RES, V47, P707
[10]   CLOSE SIMILARITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND V-ERB-B ONCOGENE PROTEIN SEQUENCES [J].
DOWNWARD, J ;
YARDEN, Y ;
MAYES, E ;
SCRACE, G ;
TOTTY, N ;
STOCKWELL, P ;
ULLRICH, A ;
SCHLESSINGER, J ;
WATERFIELD, MD .
NATURE, 1984, 307 (5951) :521-527
1234