MACROPHAGE AND T-CELL LINE TROPISMS OF HIV-1 ARE DETERMINED BY SPECIFIC REGIONS OF THE ENVELOPE GP120 GENE

被引:515
作者
SHIODA, T
LEVY, JA
CHENGMAYER, C
机构
[1] Cancer Research Institute, Department of Medicine, University of California, San Francisco
关键词
D O I
10.1038/349167a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Strains of human immunodeficiency virus type 1 (HIV-1) display a high degree of biological heterogeneity which may be linked to certain clinical manifestations of AIDS. They vary in their ability to infect different cell types 1-3, to replicate rapidly and to high titre in culture 4-6, to down-modulate the CD4 receptor 7,8, and to cause cytopathic changes in infected cells 7,9-11. Some of these in vitro properties correlate with pathogenicity of the virus in vivo 11,12. To map the viral determinants of the cellular host range of HIV-1, recombinant viruses were generated between biologically active molecular clones of HIV-1 isolates showing differences in infection of primary peripheral blood macrophages and established T-cell lines. We report here at a specific region of the envelope gp120 gene representing 159 amino-acid residues of glycoprotein gp 120 seems to determine macrophage tropism, whereas an overlapping region representing 321 amino-acid residues determines T cell-line tropism. These studies provide a basis for relating functional domains of the HIV-1 env gene to pathogenic potential.
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页码:167 / 169
页数:3
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