Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum

被引：864

作者：

Stoof, J. C. ^{[1
]}

Kebabian, J. W. ^{[1
]}

机构：

[1] NINCDS, Expt Therapeut Branch, NIH, Bethesda, MD 20205 USA

来源：

NATURE | 1981年 / 294卷 / 5839期

关键词：

D O I：

10.1038/294366a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two types of dopamine receptor whose stimulation affects cellular cyclic AMP have now been identified. In tissues as different as insect ganglia and mammalian neostriatum, stimulation of the dopamine receptor called D-1 increases formation of cyclic AMP(1-6), whereas stimulation of the second type of dopamine receptor (D-2)(7-11), first identified in the rat pituitary gland, reduces cyclic AMP formation. Recently, a receptor with the pharmacological properties of the D-2 receptor has also been found(12-14) in the rat neostriatum; we show here that stimulation of this receptor is followed by a reduction in cyclic AMP formation induced by V stimulation with D-1 agonists.

引用

页码：366 / 368

页数：3

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