RENIN INHIBITORS - DIPEPTIDE ANALOGS OF ANGIOTENSINOGEN UTILIZING A DIHYDROXYETHYLENE TRANSITION-STATE MIMIC AT THE SCISSILE BOND TO IMPART GREATER INHIBITORY POTENCY

被引：89
作者：
LULY, JR
BAMAUNG, N
SODERQUIST, J
FUNG, AKL
STEIN, H
KLEINERT, HD
MARCOTTE, PA
EGAN, DA
BOPP, B
MERITS, I
BOLIS, G
GREER, J
PERUN, TJ
PLATTNER, JJ
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 12期
关键词：
D O I：
10.1021/jm00120a005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：2264 / 2276
页数：13
相关论文
共 47 条
[11]   PURIFICATION OF HUMAN RENIN SUBSTRATE [J].
DORER, FE ;
LENTZ, KE ;
KAHN, JR ;
LEVINE, M ;
SKEGGS, LT .
ANALYTICAL BIOCHEMISTRY, 1978, 87 (01) :11-18
[12]   2-OXAZOLIDONE FORMATION BY PYROLYSIS OF BETA-IODOCARBAMATES . A STEREOSELECTIVE REACTION [J].
FOGLIA, TA ;
SWERN, D .
JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (06) :1680-&
[13]   NUCLEAR MAGNETIC-RESONANCE STUDY OF STEREOISOMERIC 2-OXAZOLIDONE AND 2-PHENYL-2-OXAZOLINE DERIVATIVES OF ALPHA-AMINO-BETA-HYDROXY ACIDS [J].
FUTAGAWA, S ;
INUI, T ;
SHIBA, T .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1973, 46 (10) :3308-3310
[14]   RENIN INHIBITORS [J].
GREENLEE, WJ .
PHARMACEUTICAL RESEARCH, 1987, 4 (05) :364-374
[15]   RENIN INHIBITORS [J].
HABER, E .
HYPERTENSION, 1986, 8 (12) :1093-1095
[16]   DIPEPTIDE GLYCOLS - A NEW CLASS OF RENIN INHIBITORS [J].
HANSON, GJ ;
BARAN, JS ;
LINDBERG, T ;
WALSH, GM ;
PAPAIOANNOU, SE ;
BABLER, M ;
BITTNER, SE ;
YANG, PC ;
DALCOROBBO, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (01) :155-161
[17]   ENHANCED POTENCY DIPEPTIDE GLYCOL RENIN INHIBITORS - STUDIES INVITRO AND IN THE CONSCIOUS RHESUS [J].
HANSON, GJ ;
BARAN, JS ;
LOWRIE, HS ;
SARUSSI, SJ ;
YANG, PC ;
BABLER, M ;
BITTNER, SE ;
PAPAIOANNOU, SE ;
WALSH, GM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (03) :959-963
[18]   RENIN INHIBITORS BASED ON NOVEL DIPEPTIDE ANALOGS - INCORPORATION OF THE DEHYDROHYDROXYETHYLENE ISOSTERE AT THE SCISSILE BOND [J].
KEMPF, DJ ;
DELARA, E ;
STEIN, HH ;
COHEN, J ;
PLATTNER, JJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (11) :1978-1983
[19]   RENIN INHIBITORS - IMPROVEMENTS IN THE STABILITY AND BIOLOGICAL-ACTIVITY OF SMALL PEPTIDES CONTAINING NOVEL LEU-VAL REPLACEMENTS [J].
KLEINERT, HD ;
LULY, JR ;
MARCOTTE, PA ;
PERUN, TJ ;
PLATTNER, JJ ;
STEIN, H .
FEBS LETTERS, 1988, 230 (1-2) :38-42
[20]   EFFECTS OF THE RENIN INHIBITOR A-64662 IN MONKEYS AND RATS WITH VARYING BASELINE PLASMA-RENIN ACTIVITY [J].
KLEINERT, HD ;
MARTIN, D ;
CHEKAL, MA ;
KADAM, J ;
LULY, JR ;
PLATTNER, JJ ;
PERUN, TJ ;
LUTHER, RR .
HYPERTENSION, 1988, 11 (06) :613-619
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