RENIN INHIBITORS - DIPEPTIDE ANALOGS OF ANGIOTENSINOGEN UTILIZING A DIHYDROXYETHYLENE TRANSITION-STATE MIMIC AT THE SCISSILE BOND TO IMPART GREATER INHIBITORY POTENCY

被引:89
作者
LULY, JR
BAMAUNG, N
SODERQUIST, J
FUNG, AKL
STEIN, H
KLEINERT, HD
MARCOTTE, PA
EGAN, DA
BOPP, B
MERITS, I
BOLIS, G
GREER, J
PERUN, TJ
PLATTNER, JJ
机构
关键词
D O I
10.1021/jm00120a005
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:2264 / 2276
页数:13
相关论文
共 47 条
[1]   3-DIMENSIONAL STRUCTURE OF HUMAN RENIN [J].
AKAHANE, K ;
UMEYAMA, H ;
NAKAGAWA, S ;
MORIGUCHI, I ;
HIROSE, S ;
IIZUKA, K ;
MURAKAMI, K .
HYPERTENSION, 1985, 7 (01) :3-12
[2]  
BOGER J, 1985, ANNU REP MED CHEM, V20, P257
[3]   RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].
BOGER, J ;
PAYNE, LS ;
PERLOW, DS ;
LOHR, NS ;
POE, M ;
BLAINE, EH ;
ULM, EH ;
SCHORN, TW ;
LAMONT, BI ;
LIN, TY ;
KAWAI, M ;
RICH, DH ;
VEBER, DF .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790
[4]   RENIN INHIBITORS - DIPEPTIDE ANALOGS OF ANGIOTENSINOGEN INCORPORATING TRANSITION-STATE, NONPEPTIDIC REPLACEMENTS AT THE SCISSILE BOND [J].
BOLIS, G ;
FUNG, AKL ;
GREER, J ;
KLEINERT, HD ;
MARCOTTE, PA ;
PERUN, TJ ;
PLATTNER, JJ ;
STEIN, HH .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (10) :1729-1737
[5]   ENKEPHALIN SYNTHESIS OF 2 PENTAPEPTIDES ISOLATED FROM PORCINE BRAIN WITH RECEPTOR-MEDIATED OPIATE AGONIST ACTIVITY [J].
BOWER, JD ;
GUEST, KP ;
MORGAN, BA .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (23) :2488-2492
[6]   SYNTHESIS OF OXAZOLIDIN-2-ONES USING CARBONATE ION ON A POLYMERIC SUPPORT [J].
CARDILLO, G ;
ORENA, M ;
SANDRI, S ;
TOMASINI, C .
TETRAHEDRON, 1985, 41 (01) :163-167
[7]   FULLY AUTOMATED SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDE HYDRAZIDES ON RECYCLING HYDROXYMETHYL RESIN [J].
CHANG, JK ;
SHIMIZU, M ;
WANG, SS .
JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (20) :3255-3258
[8]   PARTIALLY MODIFIED RETRO-INVERSO PEPTIDES - COMPARATIVE CURTIUS REARRANGEMENTS TO PREPARE 1,1-DIAMINOALKANE DERIVATIVES [J].
CHOREV, M ;
GOODMAN, M .
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1983, 21 (03) :258-268
[9]   ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID, A VERSATILE REAGENT FOR DETERMINATION OF ENANTIOMERIC COMPOSITION OF ALCOHOLS AND AMINES [J].
DALE, JA ;
DULL, DL ;
MOSHER, HS .
JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (09) :2543-&
[10]   OPTIMIZATION AND INVIVO EVALUATIONS OF A SERIES OF SMALL, POTENT, AND SPECIFIC RENIN INHIBITORS CONTAINING A NOVEL LEU-VAL REPLACEMENT [J].
DELLARIA, JF ;
MAKI, RG ;
BOPP, BA ;
COHEN, J ;
KLEINERT, HD ;
LULY, JR ;
MERITS, I ;
PLATTNER, JJ ;
STEIN, HH .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (11) :2137-2144