ACQUIRED-RESISTANCE IN MYCOBACTERIUM-AVIUM COMPLEX STRAINS ISOLATED FROM AIDS PATIENTS AND BEIGE MICE DURING TREATMENT WITH CLARITHROMYCIN

被引：25

作者：

DOUCETPOPULAIRE, F

TRUFFOTPERNOT, C

GROSSET, J

JARLIER, V

机构：

[1] Laboratoire de Bactériologie-Virologie, Faculté, De Médecine Pitié-Salpetriere

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 36卷 / 01期

关键词：

D O I：

10.1093/jac/36.1.129

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 x 10(-9). Clarithromycin resistant strains of MAC isolated in AIDS patients and beige mice as well as derivatives selected in vitro had a unique pattern of acquired cross-resistance to macrolides and related antibiotics. In contrast, the pattern of resistance to non-macrolide antibiotics remained unchanged in clarithromycin resistant strains. A dramatic decrease in ribosome affinity for clarithromycin and erythromycin was found in clarithromycin resistant strains, but no mutation was found in the peptidyl domain of the 23S rRNA, indicating that another ribosomal modification is involved.

引用

页码：129 / 136

页数：8

共 24 条

[11] MYCOBACTERIUM-AVIUM STRAINS RESISTANT TO CLARITHROMYCIN AND AZITHROMYCIN [J].

HEIFETS, L ;

MOR, N ;

VANDERKOLK, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (11) :2364-2370

[12]

JI B, 1991, 31ST INT C ANT AG CH, P147

[13] SELECTION OF RESISTANT MUTANTS OF MYCOBACTERIUM-AVIUM IN BEIGE MICE BY CLARITHROMYCIN MONOTHERAPY [J].

JI, BH ;

LOUNIS, N ;

TRUFFOTPERNOT, C ;

GROSSET, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (12) :2839-2840

[14] ALTERED METHYLATION OF RIBOSOMAL RNA IN AN ERYTHROMYCIN-RESISTANT STRAIN OF STAPHYLOCOCCUS-AUREUS [J].

LAI, CJ ;

WEISBLUM, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (04) :856-&

[15] BACTERIAL-RESISTANCE TO MACROLIDE, LINCOSAMIDE, AND STREPTOGRAMIN ANTIBIOTICS BY TARGET MODIFICATION [J].

LECLERCQ, R ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) :1267-1272

[16] IDENTIFICATION OF MUTATIONS IN 23S RIBOSOMAL-RNA GENE OF CLARITHROMYCIN-RESISTANT MYCOBACTERIUM-INTRACELLULARE [J].

MEIER, A ;

KIRSCHNER, P ;

SPRINGER, B ;

STEINGRUBE, VA ;

BROWN, BA ;

WALLACE, RJ ;

BOTTGER, EC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :381-384

[17] INVITRO ACTIVITIES OF SEVERAL NEW MACROLIDE ANTIBIOTICS AGAINST MYCOBACTERIUM-AVIUM COMPLEX [J].

NAIK, S ;

RUCK, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1614-1616

[18]

NEU HC, 1991, J ANTIMICROB CHEMOTH, V27, P1

[19] INCIDENCE OF MYCOBACTERIUM-AVIUM-INTRACELLULARE COMPLEX BACTEREMIA IN HUMAN-IMMUNODEFICIENCY-VIRUS POSITIVE PATIENTS [J].

NIGHTINGALE, SD ;

BYRD, LT ;

SOUTHERN, PM ;

JOCKUSCH, JD ;

CAL, SX ;

WYNNE, BA .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (06) :1082-1085

[20] PREVENTION OF DRUG ACCESS TO BACTERIAL TARGETS - PERMEABILITY BARRIERS AND ACTIVE EFFLUX [J].

NIKAIDO, H .

SCIENCE, 1994, 264 (5157) :382-388

← 1 2 3 →