ACQUIRED-RESISTANCE IN MYCOBACTERIUM-AVIUM COMPLEX STRAINS ISOLATED FROM AIDS PATIENTS AND BEIGE MICE DURING TREATMENT WITH CLARITHROMYCIN

被引：25

作者：

DOUCETPOPULAIRE, F

TRUFFOTPERNOT, C

GROSSET, J

JARLIER, V

机构：

[1] Laboratoire de Bactériologie-Virologie, Faculté, De Médecine Pitié-Salpetriere

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 36卷 / 01期

关键词：

D O I：

10.1093/jac/36.1.129

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clarithromycin has been reported to select clarithromycin resistant mutants of Mycobacterium avium (MAC) during treatment with clarithromycin in AIDS patients and beige mice. We selected resistant mutants in vitro at a frequency of 5 x 10(-9). Clarithromycin resistant strains of MAC isolated in AIDS patients and beige mice as well as derivatives selected in vitro had a unique pattern of acquired cross-resistance to macrolides and related antibiotics. In contrast, the pattern of resistance to non-macrolide antibiotics remained unchanged in clarithromycin resistant strains. A dramatic decrease in ribosome affinity for clarithromycin and erythromycin was found in clarithromycin resistant strains, but no mutation was found in the peptidyl domain of the 23S rRNA, indicating that another ribosomal modification is involved.

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页码：129 / 136

页数：8

相关论文

共 24 条

[1] MYCOBACTERIA POSSESS A SURPRISINGLY SMALL NUMBER OF RIBOSOMAL-RNA GENES IN RELATION TO THE SIZE OF THEIR GENOME [J].

BERCOVIER, H ;

KAFRI, O ;

SELA, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 136 (03) :1136-1141

[2] COMPARATIVE INVITRO ACTIVITY OF THE NEW MACROLIDE A-56268 AGAINST MYCOBACTERIA [J].

BERLIN, OGW ;

YOUNG, LS ;

FLOYDREISING, SA ;

BRUCKNER, DA .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1987, 6 (04) :486-487

[3] ACTIVITIES OF CLARITHROMYCIN AGAINST 8 SLOWLY GROWING SPECIES OF NONTUBERCULOUS MYCOBACTERIA, DETERMINED BY USING A BROTH MICRODILUTION MIC SYSTEM [J].

BROWN, BA ;

WALLACE, RJ ;

ONYI, GO .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (09) :1987-1990

[4]

CANETTI G, 1963, Rev Tuberc Pneumol (Paris), V27, P217

[5]

COOPERMAN BS, 1990, RIBOSOME, P491

[6] POINT MUTATIONS IN THE 23-S RIBOSOMAL-RNA GENES OF 4 LINCOMYCIN RESISTANT NICOTIANA-PLUMBAGINIFOLIA MUTANTS COULD PROVIDE NEW SELECTABLE MARKERS FOR CHLOROPLAST TRANSFORMATION [J].

CSEPLO, A ;

ETZOLD, T ;

SCHELL, J ;

SCHREIER, PH .

MOLECULAR AND GENERAL GENETICS, 1988, 214 (02) :295-299

[7] CLARITHROMYCIN AND OTHER ANTIMICROBIAL AGENTS IN THE TREATMENT OF DISSEMINATED MYCOBACTERIUM-AVIUM INFECTIONS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

DAUTZENBERG, B ;

SAINTMARC, T ;

MEYOHAS, MC ;

ELIASZEWITCH, M ;

HANIEZ, F ;

ROGUES, AM ;

DEWIT, S ;

COTTE, L ;

CHAUVIN, JP ;

GROSSET, J .

ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (03) :368-372

[8] ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL [J].

DAUTZENBERG, B ;

TRUFFOT, C ;

LEGRIS, S ;

MEYOHAS, MC ;

BERLIE, HC ;

MERCAT, A ;

CHEVRET, S ;

GROSSET, J .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (03) :564-569

[9] DNA AMPLIFICATION AND REVERSE DOT BLOT HYBRIDIZATION FOR DETECTION AND IDENTIFICATION OF MYCOBACTERIA TO THE SPECIES LEVEL IN THE CLINICAL LABORATORY [J].

FISS, EH ;

CHEHAB, FF ;

BROOKS, GF .

JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (05) :1220-1224

[10] GENERATION OF SINGLE-STRANDED-DNA BY THE POLYMERASE CHAIN-REACTION AND ITS APPLICATION TO DIRECT SEQUENCING OF THE HLA-DQA LOCUS [J].

GYLLENSTEN, UB ;

ERLICH, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7652-7656