RANDOMIZED TRIAL OF PREVENTION OF BILIARY STENT OCCLUSION BY URSODEOXYCHOLIC ACID PLUS NORFLOXACIN

被引：72
作者：
BARRIOZ, T
INGRAND, P
BESSON, I
DELEDINGHEN, V
SILVAIN, C
BEAUCHANT, M
机构：
[1] UNIV HOSP POITIERS,HEPATOL UNIT,F-86021 POITIERS,FRANCE
[2] UNIV POITIERS,FAC MED,DEPT BIOSTAT,POITIERS,FRANCE
来源：
LANCET | 1994年 / 344卷 / 8922期
关键词：
D O I：
10.1016/S0140-6736(94)91967-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Biliary stents are liable to clog. We investigated whether a choleretic plus an antibiotic could delay clogging. 20 consecutive patients with a malignant biliary stricture were randomised after endoscopic insertion of a polyethylene stent to receive ursodeoxycholic acid plus norfloxacin (13-15 mg/kg and 400 mg, daily) or conservative treatment. The drug combination was associated with: a longer median patency of first (49 vs 6 weeks) and all stents (38 vs 7 weeks); a prolonged median survival (67 vs 18 weeks); and a shorter mean hospital stay (0.2 vs 1.0 days per week of survival). Thus ursodeoxycholic acid plus norfloxacin may prevent stent clogging.
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收藏
页码：581 / 582
页数：2
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