THE EFFECT OF L-CARNITINE ON CHOLESTEROL-METABOLISM IN RAT (RATTUS-BUBALUS) HEPATOCYTE CELLS

被引：26

作者：

MONDOLA, P ^{[1
]}

SANTILLO, M ^{[1
]}

DEMERCATO, R ^{[1
]}

SANTANGELO, F ^{[1
]}

机构：

[1] NAPLES UNIV,FAC MED CHIRURG 2,IST MED PUBBLICA SICUREZZA SOCIALE,I-80125 NAPLES,ITALY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 07期

关键词：

D O I：

10.1016/0020-711X(92)90372-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. This paper concerns the study of the effect of L-carnitine on cholesterol metabolism in rat hepatocyte cells BRL-3A. In this research the binding of [I-125]human low density lipoprotein (LDL) to BRL-3A cells and 3-hydroxy 3-methylglutaryl CoA reductase activity (HMG-CoA reductase activity) after L-carnitine incubation were studied. 2. It was found that L-carnitine is able to increase either the [I-125]LDL binding or inhibit the HMG-CoA reductase activity in BRL-3A cells. 3. These results indicate that L-carnitine affects the cholesterol metabolism through an inhibition of HMG-CoA reductase activity that could be responsible for the increased [I-125]LDL binding in rat hepatocytes.

引用

页码：1047 / 1050

页数：4

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