VASCULAR SODIUM-PUMP ACTIVITY KINETICS IN EARLY AND ADVANCED STAGES OF DEOXYCORTICOSTERONE-SALT HYPERTENSION IN RATS

被引:8
|
作者
SONGUMIZE, E
机构
[1] UNIV TENNESSEE,CTR HLTH SCI,COLL MED,DEPT PHARMACOL,MEMPHIS,TN 38163
[2] HLTH SCI CTR,MEMPHIS,TN 38163
关键词
D O I
10.1016/0024-3205(91)90647-T
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We determined the kinetic properties--the maximal velocity, V(max), and the half-maximal activating concentration of K+, k(m) values--of the vascular sodium pump in rats 6, 28, and 50 days after deoxycorticosterone and sodium chloride (DOC-salt) or vehicle treatment. Tail arteries from six or eight rats from each treatment group were pooled, and Na-pump activity was measured in a Krebs medium containing varying K+ (plus Rb-86(+)) concentrations (0.25-10 mM). Na-pump activity was plotted as a function of [K + Rb-86]. Data were fit to a two-site model to calculate V(max) and k(m) values. Systolic blood pressures were normal after 6 days but high after 28 and 50 days of DOC-salt treatment. No difference in kinetic parameters existed between the treatment and control groups 6 and 50 days after DOC-salt treatment. After 28 days, V(max) was significantly elevated compared with controls; k(m) was not affected. Thus, stimulation of the vascular Na-pump during established hypertension is due to an increase in the maximal velocity of ouabain-sensitive uptake of K+.
引用
收藏
页码:2045 / 2052
页数:8
相关论文
共 50 条
  • [31] Endothelin and sympathetic nervous system activity contribute to increased venomotor tone in deoxycorticosterone-salt hypertension
    Fink, GD
    Johnson, RJ
    Galligan, JJ
    HYPERTENSION, 1999, 34 (02) : 330 - 330
  • [32] INCREASING DIETARY CALCIUM AUGMENTS GLOMERULAR CAPILLARY HYPERTENSION AND WORSENS GLOMERULAR INJURY IN RATS WITH DEOXYCORTICOSTERONE-SALT (DOC-SALT) HYPERTENSION
    DWORKIN, LD
    FEINER, HD
    RANDAZZO, J
    KIDNEY INTERNATIONAL, 1986, 29 (01) : 244 - 244
  • [33] CHANGES IN RENAL VASCULAR REACTIVITY AT VARIOUS STAGES OF DEOXYCORTICOSTERONE HYPERTENSION IN RATS
    BERECEK, KH
    STOCKER, M
    GROSS, F
    CIRCULATION RESEARCH, 1980, 46 (05) : 619 - 624
  • [34] INHIBITION OF SODIUM-PUMP ACTIVITY AND VASCULAR RESPONSIVENESS IN SHR AND WKY
    LAMB, FS
    MORELAND, RS
    WEBB, RC
    CLINICAL RESEARCH, 1983, 31 (04): : A814 - A814
  • [35] CONTRIBUTION OF VASOPRESSIN TO THE MAINTENANCE OF BLOOD-PRESSURE IN DEOXYCORTICOSTERONE-SALT INDUCED MALIGNANT HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
    HIWATARI, M
    ABRAHAMS, JM
    SAITO, T
    JOHNSTON, CI
    CLINICAL SCIENCE, 1986, 70 (02) : 191 - 198
  • [36] EFFECT OF OUABAIN, A SODIUM-PUMP INHIBITOR, ON THE DEVELOPMENT OF HYPERTENSION IN DAHL RATS
    HUSAIN, A
    BUMPUS, FM
    IDEISHI, M
    YOUNG, D
    SEN, S
    FEDERATION PROCEEDINGS, 1986, 45 (04) : 1070 - 1070
  • [37] Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats
    White, RM
    Rivera, CO
    Davison, CB
    HYPERTENSION, 1996, 27 (06) : 1245 - 1253
  • [38] Adenovirus-mediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxycorticosterone-salt rats
    Dobrzynski, E
    Yoshida, H
    Chao, J
    Chao, L
    IMMUNOPHARMACOLOGY, 1999, 44 (1-2): : 57 - 65
  • [39] A CIRCULATING SODIUM-PUMP INHIBITOR IN ESSENTIAL-HYPERTENSION AND NORMOTENSIVE SUBJECTS, WITH THE EFFECT OF SALT
    UMEDA, T
    NAOMI, S
    INOUE, J
    MIURA, F
    IWAOKA, T
    HAMASAKI, S
    FUJII, Y
    OHNO, M
    SATO, T
    CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1985, 7 (04) : 621 - 621
  • [40] ALTERATIONS OF MEMBRANE SODIUM-PUMP ACTIVITY IN STREPTOZOTOCIN (STZ) DIABETIC RATS
    KIM, HY
    KU, DD
    FEDERATION PROCEEDINGS, 1981, 40 (03) : 612 - 612