SECRETION AND ELIMINATION OF INSULIN BY THE INVITRO PERFUSED PANCREAS AND LIVER OF RATS WITH THIOACETAMIDE-INDUCED LIVER-CIRRHOSIS

被引：1

作者：

BROMME, HJ ^{[1
]}

ZIMMERMANN, T ^{[1
]}

BLECH, W ^{[1
]}

机构：

[1] UNIV JENA,INST PATHOL BIOCHEM,O-6900 JENA,GERMANY

来源：

HORMONE AND METABOLIC RESEARCH | 1991年 / 23卷 / 06期

关键词：

INSULIN; LIVER; PANCREAS; RAT; THIOACETAMIDE; CIRRHOSIS;

D O I：

10.1055/s-2007-1003669

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pancreatic secretion and hepatic removal of insulin have been measured in thioacetamide (TAA)-induced compensated rat liver cirrhosis in perfusion experiments. Peripheral plasma concentrations of glucose and insulin were slightly decreased in TAA-treated rats. Pancreatic secretion and hepatic removal of insulin remained unchanged by the TAA-treatment. Thus, even in morphologically and biochemically proven experimental liver cirrhosis, insulin secretion and removal may not be disturbed.

引用

收藏

页码：262 / 265

页数：4

相关论文

共 18 条

[1] INSULIN AND GLUCAGON DEGRADATION IN LIVER ARE NOT AFFECTED BY HEPATIC CIRRHOSIS [J].

ANTONIELLO, S ;

LAROCCA, S ;

CAVALCANTI, E ;

AULETTA, M ;

SALVATORE, F ;

CACCIATORE, L .

CLINICA CHIMICA ACTA, 1989, 183 (03) :343-350

[2]

BIERWOLF B, 1976, ACTA BIOL MED GER, V35, P583

[3] HYPERINSULINEMIA OF CHRONIC ACTIVE HEPATITIS - IMPAIRED INSULIN REMOVAL RATHER THAN PANCREATIC HYPERSECRETION [J].

BONORA, E ;

COSCELLI, C ;

ORIOLI, S ;

CAMBI, R ;

BUZZELLI, G ;

GENTILINI, P ;

BUTTURINI, U .

HORMONE AND METABOLIC RESEARCH, 1984, 16 (03) :111-114

[4] ROLE OF SPONTANEOUS PORTAL-SYSTEMIC SHUNTING IN HYPERINSULINISM OF CIRRHOSIS [J].

BOSCH, J ;

GOMIS, R ;

KRAVETZ, D ;

CASAMITJANA, R ;

TERES, J ;

RIVERA, F ;

RODES, J .

AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (03) :G206-G212

[5]

Bromme H J, 1987, Z Exp Chir Transplant Kunstliche Organe, V20, P250

[6] SERUM LEVELS OF TRUE INSULIN, C-PEPTIDE AND PROINSULIN IN PERIPHERAL-BLOOD OF PATIENTS WITH CIRRHOSIS [J].

KASPERSKACZYZYKOWA, T ;

HEDING, LG ;

CZYZYK, A .

DIABETOLOGIA, 1983, 25 (06) :506-509

[7]

MISBIN RI, 1985, DIETARY FIBER OBESIT, P19

[8]

MULLER A, 1988, EXP PATHOL-JENA, V34, P229

[9] INSULIN UPTAKE BY THE HUMAN ALCOHOLIC CIRRHOTIC LIVER [J].

NYGREN, A ;

ADNER, N ;

SUNDBLAD, L ;

WIECHEL, KL .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1985, 34 (01) :48-52

[10] INSULIN AND C-PEPTIDE IN CHRONIC LIVER-DISEASE DURING ORAL GLUCOSE-TOLERANCE TESTING [J].

OEHLER, G ;

KNECHT, M ;

BLEYL, H ;

MATTHES, KJ .

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1984, 109 (07) :253-257