BACTERICIDAL PERMEABILITY INCREASING PROTEIN AND HOST DEFENSE AGAINST GRAM-NEGATIVE BACTERIA AND ENDOTOXIN

被引：106

作者：

ELSBACH, P

WEISS, J

机构：

[1] New York University School of Medicine, New York, NY

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期

关键词：

D O I：

10.1016/0952-7915(93)90088-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.

引用

页码：103 / 107

页数：5

共 27 条

[1]

CROWL RM, 1991, J BIOL CHEM, V266, P2647

[2]

Elsbach P, 1992, INFLAMMATION BASIC P, P603

[3] HIGH-AFFINITY BINDING OF THE BACTERICIDAL PERMEABILITY-INCREASING PROTEIN AND A RECOMBINANT AMINO-TERMINAL FRAGMENT TO THE LIPID-A REGION OF LIPOPOLYSACCHARIDE [J].