PRIMARY SJOGRENS-SYNDROME WITH ANTIBODIES TO HTLV-I - CLINICAL AND LABORATORY FEATURES

被引：126

作者：

EGUCHI, K ^{[1
]}

MATSUOKA, N ^{[1
]}

IDA, H ^{[1
]}

NAKASHIMA, M ^{[1
]}

SAKAI, M ^{[1
]}

SAKITO, S ^{[1
]}

KAWAKAMI, A ^{[1
]}

TERADA, K ^{[1
]}

SHIMADA, H ^{[1
]}

KAWABE, Y ^{[1
]}

FUKUDA, T ^{[1
]}

SAWADA, T ^{[1
]}

NAGATAKI, S ^{[1
]}

机构：

[1] EISAI & CO LTD,TSUKUBA RES LABS,IBARAKI 30026,JAPAN

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 06期

关键词：

D O I：

10.1136/ard.51.6.769

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of antibodies to human T lymphotropic virus type I (HTLV-I) was studied in patients with primary Sjogren's syndrome. Thirteen of 36 serum samples were positive by enzyme linked immunosorbent assay (ELISA) and particle agglutination assay for antibodies to HTLV-I and were confirmed by western blotting. The presence of antibodies to HTLV-I may signify an HTLV-I carrier state. These patients had a high occurrence of extraglandular manifestations such as uveitis, myopathy, and recurrent high fever compared with patients who did not have antibodies to HTLV-I. Patients with antibodies to HTLV-I had an increased spontaneous proliferation of peripheral blood mononuclear cells compared with those without the antibodies. The proportions of activated and memory T cells (HLA-DR+CD3+, CD25+CD3+, and CD29+CD4+ cells) were higher in HTLV-I carriers than in non-carriers. The presence of antibodies to HTLV-I in some patients with primary Sjogren's syndrome suggests that HTLV-I may cause primary Sjogren's syndrome or its extraglandular manifestations, or both.

引用

页码：769 / 776

页数：8

共 44 条

[1] DETECTION OF HUMAN T-CELL LYMPHOMA LEUKEMIA-VIRUS TYPE-I DNA AND ANTIGEN IN SPINAL-FLUID AND BLOOD OF PATIENTS WITH CHRONIC PROGRESSIVE MYELOPATHY [J].