POSSIBLE BINDING-SITE OF THYROTROPIN BINDING INHIBITOR IMMUNOGLOBULIN (TBII) ON THE THYROTROPIN (TSH) RECEPTOR, WHICH IS DIFFERENT FROM TSH BINDING-SITE

被引：24
|
作者：
PIRAPHATDIST, T [1 ]
SUGAWA, H [1 ]
INOUE, D [1 ]
ENOMOTO, T [1 ]
MORI, T [1 ]
IMURA, H [1 ]
机构：
[1] KYOTO UNIV,FAC MED,DIV INTERNAL MED 2,KYOTO 606,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)90705-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A synthetic decapeptide, P-194, which has the sequence No. 103 to 111 of hTSH receptor structure with an additional N-terminal tyrosine, did not bind TSH nor affected its receptor binding and thyroid stimulating activity. Preincubation of P-194 with sera from thyroid patients caused a significant decrease in TBII activity in almost all 12 TBII positive sera and an increase of thyroid stimulating activity in 3 of 7 Graves' IgG studied. In addition, [125I] P-194 bound to serum IgG fraction from thyroid patients with a positive correlation with TBII (N=35, r=0.509, p<0.01). The P-194 portion may be, at least a part of, TBII binding site distinct from the TSH binding site on the TSH receptor. © 1990.
引用
收藏
页码：529 / 536
页数：8
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