POSSIBLE BINDING-SITE OF THYROTROPIN BINDING INHIBITOR IMMUNOGLOBULIN (TBII) ON THE THYROTROPIN (TSH) RECEPTOR, WHICH IS DIFFERENT FROM TSH BINDING-SITE

被引：24

作者：

PIRAPHATDIST, T ^{[1
]}

SUGAWA, H ^{[1
]}

INOUE, D ^{[1
]}

ENOMOTO, T ^{[1
]}

MORI, T ^{[1
]}

IMURA, H ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DIV INTERNAL MED 2,KYOTO 606,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90705-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A synthetic decapeptide, P-194, which has the sequence No. 103 to 111 of hTSH receptor structure with an additional N-terminal tyrosine, did not bind TSH nor affected its receptor binding and thyroid stimulating activity. Preincubation of P-194 with sera from thyroid patients caused a significant decrease in TBII activity in almost all 12 TBII positive sera and an increase of thyroid stimulating activity in 3 of 7 Graves' IgG studied. In addition, [125I] P-194 bound to serum IgG fraction from thyroid patients with a positive correlation with TBII (N=35, r=0.509, p<0.01). The P-194 portion may be, at least a part of, TBII binding site distinct from the TSH binding site on the TSH receptor. © 1990.

引用

页码：529 / 536

页数：8

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