GENOTYPING STUDY OF ALCOHOL-DEHYDROGENASE CLASS-I POLYMORPHISM IN FRENCH PATIENTS WITH ALCOHOLIC CIRRHOSIS

被引：48
作者：
COUZIGOU, P
FLEURY, B
GROPPI, A
CASSAIGNE, A
BEGUERET, J
IRON, A
机构：
[1] HAUT LEVEQUE HOSP, DEPT HEPATOGASTROENTEROL, F-33604 PESSAC, FRANCE
[2] UNIV BORDEAUX 2, DEPT GENET, F-33076 BORDEAUX, FRANCE
[3] UNIV BORDEAUX 2, DEPT BIOCHEM, F-33076 BORDEAUX, FRANCE
来源：
ALCOHOL AND ALCOHOLISM | 1990年 / 25卷 / 06期
关键词：
D O I：
10.1093/oxfordjournals.alcalc.a045058
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Comparison of alcohol dehydrogenase polymorphism at the loci ADH2 and ADH3 is made in France between 46 alcoholic cirrhotic patients and 39 controls, by genotyping technique using polymerase chain reaction on blood microsample collected on blotting paper. The genotype distributions are similar, with low frequency of the ADH2(2) allele. Polymorphism at the ADH3 locus is not a genetic factor for alcoholic cirrhosis in France.
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页码：623 / 626
页数：4
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