FACTOR REQUIRED FOR MAMMALIAN SPLICEOSOME ASSEMBLY IS LOCALIZED TO DISCRETE REGIONS IN THE NUCLEUS

被引：661
作者：
FU, XD
MANIATIS, T
机构：
[1] Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
来源：
NATURE | 1990年 / 343卷 / 6257期
关键词：
D O I：
10.1038/343437a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus. © 1990 Nature Publishing Group.
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页码：437 / 441
页数：5
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