DOUBLE-BLIND COMPARISON OF SULFONAMIDE-TRIMETHOPRIM COMBINATIONS IN ACUTE UNCOMPLICATED URINARY-TRACT INFECTIONS

被引：7
作者：
SKJERVEN, O
BERGAN, T
机构：
[1] UNIV HOSP TROMSO,INST PHARM,DEPT MICROBIOL,TROMSO,NORWAY
[2] UNIV OSLO,INST PHARM,DEPT MICROBIOL,OSLO,NORWAY
来源：
INFECTION | 1979年 / 7卷
关键词：
D O I：
10.1007/BF01639020
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The effects of a twice daily dosage of a combination of 410 mg sulphadiazine + 90 mg trimethoprim (SD + TMP) and 800 mg sulphamethoxazole + 160 mg trimethoprim (SMZ + TMP) were compared in uncomplicated urinary tract infections. All but one patient in each treatment group, i.e. 36 SD + TMP treated and 42 SMZ + TMP treated patients respectively, were cured. The percentage of side-effects related to therapy in the patients receiving the combination with sulphadiazine was 15.1% and in those with sulphamethoxazole 23.7%. Due to the small number tested, however, differences were not statistically different. It is noteworthy that only one of the SD + TMP patients had to stop therapy because of a rash, whereas therapy was stopped for this reason in three of the SMZ + TMP patients. SD + TMP represents a good alternative to SMZ + TMP in the treatment of urinary tract infections. © 1979 Verlagsgesellschaft Otto Spatz.
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页码：S398 / S400
页数：3
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