PHASE-II EVALUATION OF SINGLE-AGENT CARBOPLATIN IN ADVANCED THYROID-CARCINOMA

被引：0

作者：

ONG, ST

DEGROOT, LJ

VOGELZANG, NJ

机构：

[1] UNIV CHICAGO,DEPT MED,DIV BIOL SCI,HEMATOL ONCOL SECT,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT MED,DIV BIOL SCI,ENDOCRINOL SECT,CHICAGO,IL 60637

来源：

ONCOLOGY REPORTS | 1994年 / 1卷 / 06期

关键词：

CARBOPLATIN; THYROID CARCINOMA;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Single agent carboplatin was used in a phase II trial to treat patients with metastatic thyroid cancer who had failed surgery, radiation therapy, or radioactive iodine. Carboplatin was administered at a dose of 400 mg/m(2) every 28 days on an outpatient basis. Eight patients with a variety of tumor histologies were enrolled. No patient had a response to treatment and the average time to disease progression while on treatment was 5.4 months. Toxicity was mild and included hearing loss in one patient. There have been few studies using newer agents in patients with metastatic thyroid cancer who failed surgery and radioactive iodine. These results underline the need for larger intergroup trials with newer agents.

引用

页码：1217 / 1218

页数：2