COMPATIBILITY STUDY BETWEEN ATENOLOL AND TABLET EXCIPIENTS USING DIFFERENTIAL SCANNING CALORIMETRY

被引：33

作者：

BOTHA, SA

LOTTER, AP

机构：

[1] Research Institute for Industrial Pharmacy University of Potchefstroom, C.H.E. 2520, Potchefstroom

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 12期

关键词：

D O I：

10.3109/03639049009028349

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to improve the formulation of atenolol the physico-chemical compatibility between the drug and various excipients, commonly used in tablet manufacturing, was studied with the aid of Differential Scanning Calorimetry (DSC). Using this method, it was found that atenolol is compatible with starch, Sta-Rx® Primojel® Avicel PH® Ac-Di-Sol® cross-linked PVP, magnesium stearate, calcium sulphate dihydrate, dicalcium phosphate and icing sugar. Interactions of atenolol with PVP, lactose and the lubricant stearic acid were found, although it cannot be conlusively stated that interaction incompatibilities will occur during storage at room temperature. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1945 / 1954

页数：10

共 16 条

[1] DSC SCREENING FOR DRUG-DRUG AND DRUG-EXCIPIENT INTERACTIONS IN POLYPHARMACEUTICALS INTENDED FOR THE ALLEVIATION OF THE SYMPTOMS OF COLDS AND FLU .1. [J].