IDENTIFICATION OF 3 PREVIOUSLY UNREPORTED LINDANE METABOLITES FROM MAMMALS

被引：11

作者：

CHADWICK, RW

FREAL, JJ

SOVOCOOL, GW

BRYDEN, CC

COPELAND, MF

机构：

[1] Environmental Protection Agy. Environmental Research Center Health Effects Research Laboratory Envir

来源：

CHEMOSPHERE | 1978年 / 7卷 / 08期

关键词：

D O I：

10.1016/0045-6535(78)90085-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Previously unreported metabolites from the urine of rats treated with lindane have been identified as configurational isomers of 2,4,5,6- and 2,3,4,6-tetrachloro-2-cyclohexen-1-ol. In addition, an intermediate metabolite from the incubation of lindane with liver preparations, under N2, has been identified as the configurational isomer γ-3,4,5,6-tetrachlorocyclohex-1-ene. The pathways leading to these metabolites appear to have an important role in the metabolism of lindane by mammals. © 1978.

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页码：633 / 640

页数：8

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