CUMULATIVE RISK OF HEPATOCELLULAR-CARCINOMA IN HEPATITIS-C VIRUS CARRIERS - STATISTICAL ESTIMATIONS FROM CROSS-SECTIONAL DATA

被引：26
作者：
TANAKA, H [1 ]
HIYAMA, T [1 ]
TSUKUMA, H [1 ]
FUJIMOTO, I [1 ]
YAMANO, H [1 ]
OKUBO, Y [1 ]
KITADA, A [1 ]
机构：
[1] OSAKA RED CROSS, CTR BLOOD, JOTOU KU, OSAKA 536, JAPAN
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 05期
关键词：
HEPATITIS C VIRUS; HEPATOCELLULAR CARCINOMA; HEPATITIS C VIRUS CARRIER; CUMULATIVE RISK; EPIDEMIOLOGY;
D O I：
10.1111/j.1349-7006.1994.tb02384.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The probability of developing hepatocellular carcinoma (HCC) among hepatitis C virus (HCV) carriers during their life-time is unknown. This paper addresses the estimation of the cumulative risk of HCC among HCV carriers using cross-sectional data. Age specific prevalences of HCV carriers among the general population were estimated according to 5-year age group, based on the data of 2nd- generation anti-HCV assay in blood donors resident in Osaka (33,226 males and 29,054 females). Seropositivity of anti-HCV among 422 HCC cases, and the Osaka Cancer Registry data on HCC were used in the estimations of 5-year age-specific incidence rates of HCV-linked HCC. Using these data, the cumulative risk, i.e., the probability of contracting HCC within the following 15 years in 50-year-old HCV carriers, was estimated as 28% for males and 6% for females.
引用
收藏
页码：485 / 490
页数：6
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