ACRIDINE-DERIVATIVES .5. SYNTHESIS AND P388 ANTITUMOR-ACTIVITY OF THE NOVEL 9-ANILINO-2,3-ETHYLENEDIOXYACRIDINES

被引：14

作者：

KIMURA, M ^{[1
]}

OKABAYASHI, I ^{[1
]}

KATO, A ^{[1
]}

机构：

[1] NIIGATA COLL PHARM, NIIGATA 95021, JAPAN

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 04期

关键词：

D O I：

10.1002/jhet.5570300446

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of deoxyribonucleic acid (DNA)-intercalating antitumor agents, novel 9-anilino-2,3-ethylenedioxyacridines (five compounds) have been synthesized and evaluated for activity against P388 leukemia in vivo. A few of them possessed the same potency of antitumor activity as amsacrine (m-AMSA) which is an important antitumor agent in clinical use.

引用

页码：1101 / 1104

页数：4

共 30 条

[1]

ACHESON A, 1956, ACRIDINES, P148

[2]

ALBERT A, 1966, ACRIDINES, P403

[3] EXPERIMENTAL ANTITUMOR PROPERTIES OF 3 CONGENERS OF ACRIDYLMETHANESULFONANILIDE (AMSA) SERIES [J].