PHENOTYPIC VARIATION OF CARBOHYDRATE SURFACE-ANTIGENS AND THE PATHOGENESIS OF HAEMOPHILUS-INFLUENZAE INFECTIONS

被引：27

作者：

ROCHE, RJ ^{[1
]}

MOXON, ER ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP, INST MOLEC MED, DEPT PAEDIAT, MOLEC INFECT DIS GRP, OXFORD OX3 9DU, ENGLAND

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0966-842X(00)88959-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic variation of two major carbohydrate surface antigens of Haemophilus influenzae, the capsule and lipopolysaccharide, exemplifies some of the genetic mechanisms used by pathogenic bacteria in interacting with host micoenvironments. The ability to generate phenotypic variety at high frequency within clonal populations of microorganisms provides an adaptive mechanism to combat the polymorphisms and immune repertoires of the host.

引用

页码：304 / 309

页数：6

共 60 条

[1] CAPSULATION GENE LOSS AND RESCUE MUTATIONS DURING THE CAP+ TO CAP- TRANSITION IN HAEMOPHILUS-INFLUENZAE TYPE-B [J].

BROPHY, LN ;

KROLL, JS ;

FERGUSON, DJP ;

MOXON, ER .

JOURNAL OF GENERAL MICROBIOLOGY, 1991, 137 :2571-2576

[2]

BROWN JE, 1991, REV INFECT DIS, V13, pS298

[3] ERYTHROCYTE-P ANTIGEN - CELLULAR RECEPTOR FOR B19 PARVOVIRUS [J].

BROWN, KE ;

ANDERSON, SM ;

YOUNG, NS .

SCIENCE, 1993, 262 (5130) :114-117

[4] MOLECULAR-CLONING OF A GENE INVOLVED IN LIPOOLIGOSACCHARIDE BIOSYNTHESIS AND VIRULENCE EXPRESSION BY HAEMOPHILUS-INFLUENZAE TYPE-B [J].

COPE, LD ;

YOGEV, R ;

MERTSOLA, J ;

LATIMER, JL ;

HANSON, MS ;

MCCRACKEN, GH ;

HANSEN, EJ .

MOLECULAR MICROBIOLOGY, 1991, 5 (05) :1113-1124

[5] GENES INVOLVED IN HAEMOPHILUS-INFLUENZAE TYPE-B CAPSULE EXPRESSION ARE FREQUENTLY AMPLIFIED [J].

CORN, PG ;

ANDERS, J ;

TAKALA, AK ;

KAYHTY, H ;

HOISETH, SK .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (02) :356-364

[6] ULTRASTRUCTURAL CHARACTERIZATION OF CAPSULATED HEMOPHILUS-INFLUENZAE TYPE-B AND 2 SPONTANEOUS NONTYPABLE MUTANTS [J].

DOERN, GV ;

BUCKMIRE, FLA .

JOURNAL OF BACTERIOLOGY, 1976, 127 (01) :523-535

[7] EFFICACY OF HAEMOPHILUS-INFLUENZAE TYPE-B POLYSACCHARIDE DIPHTHERIA TOXOID CONJUGATE VACCINE IN INFANCY [J].

ESKOLA, J ;

PELTOLA, H ;

TAKALA, AK ;

KAYHTY, H ;

HAKULINEN, M ;

KARANKO, V ;

KELA, E ;

REKOLA, P ;

RONNBERG, PR ;

SAMUELSON, JS ;

GORDON, LK ;

MAKELA, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (12) :717-722

[8] COMMON THEMES IN MICROBIAL PATHOGENICITY [J].

FINLAY, BB ;

FALKOW, S .

MICROBIOLOGICAL REVIEWS, 1989, 53 (02) :210-230

[9] CHARACTERIZATION OF LIPOPOLYSACCHARIDE OF HEMOPHILUS-INFLUENZAE [J].

FLESHER, AR ;

INSEL, RA .

JOURNAL OF INFECTIOUS DISEASES, 1978, 138 (06) :719-730

[10] HAEMOPHILUS-INFLUENZAE RESIDES AND MULTIPLIES INTRACELLULARLY IN HUMAN ADENOID TISSUE AS DEMONSTRATED BY IN-SITU HYBRIDIZATION AND BACTERIAL VIABILITY ASSAY [J].

FORSGREN, J ;

SAMUELSON, A ;

AHLIN, A ;

JONASSON, J ;

RYNNELDAGOO, B ;

LINDBERG, A .

INFECTION AND IMMUNITY, 1994, 62 (02) :673-679

← 1 2 3 4 5 6 →