GENETIC CONTROL OF ANTIBODY RESPONSE - RELATIONSHIP BETWEEN IMMUNE RESPONSE AND HISTOCOMPATIBILITY (H-2) TYPE

被引：384

作者：

MCDEVITT, HO

CHINITZ, A

机构：

[1] Department of Medicine, Stanford University, School of Medicine, Stanford

来源：

SCIENCE | 1969年 / 163卷 / 3872期

关键词：

D O I：

10.1126/science.163.3872.1207

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The immune responses of inbred mice to a related series of three synthetic polypeptide antigens are genetically controlled traits which are closely correlated with the genotype for the major histocompatibility (H-2) locus. All strains of the same H-2 type exhibit the same pattern of immune response, independent of the remainder of a given strain's genetic background. There is marked antigen-specific polymorphism between strains of different H-2 types with respect to their patterns of response.

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页码：1207 / &

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