TREATMENT OF NEUTROPENIA IN FELTYS SYNDROME WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - HEMATOLOGICAL RESPONSE ACCOMPANIED BY PULMONARY COMPLICATIONS WITH LETHAL OUTCOME

被引：4

作者：

GARIBAI, AR ^{[1
]}

ROCHLITZ, C ^{[1
]}

RIEWALD, M ^{[1
]}

OERTEL, J ^{[1
]}

HUHN, D ^{[1
]}

机构：

[1] FREE UNIV BERLIN,DEPT INTERNAL MED,DIV HEMATOL ONCOL,W-1000 BERLIN 19,GERMANY

来源：

ANNALS OF HEMATOLOGY | 1992年 / 65卷 / 05期

关键词：

NEUTROPENIA; FELTYS SYNDROME; PULMONARY COMPLICATION; GM-CSF;

D O I：

10.1007/BF01703951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a 67-year-old man with Felty's syndrome (FS) complicated by recurrent pneumonia and an infected wound, which was not healing in spite of maximal antibiotic and local therapy. Encouraged by previous experience, we treated him with granulocyte-macrophage colony-stimulating factor (GM-CSF). His total leukocyte count rose, but the patient's pneumonia deteriorated. In addition, a previously known chronic obstructive lung disease (COLD) was exacerbated acutely. These complications finally led to his death. Postmortem examination revealed widespread pneumonia with invasive aspergillosis and a peripheral adenocarcinoma in his left lung.

引用

页码：232 / 235

页数：4

共 31 条

[21] HEMATOPOIETIC GROWTH-FACTORS - OVERVIEW AND CLINICAL-APPLICATIONS .3.
ROBINSON, BE
QUESENBERRY, PJ
[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1990, 300 (05) : 311 - 321
[22] HEMATOPOIETIC GROWTH-FACTORS - OVERVIEW AND CLINICAL-APPLICATIONS .2.
ROBINSON, BE
QUESENBERRY, PJ
[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1990, 300 (04) : 237 - 244
[23] HEMATOPOIETIC GROWTH-FACTORS - OVERVIEW AND CLINICAL-APPLICATIONS .1.
ROBINSON, BE
QUESENBERRY, PJ
[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1990, 300 (03) : 163 - 170
[24] SISSON SD, 1988, BLOOD, V72, P1368
[25] CLINICAL-APPLICATIONS OF MYELOID COLONY STIMULATING FACTORS
STEWARD, WP
THATCHER, N
KAYE, SB
[J]. CANCER TREATMENT REVIEWS, 1990, 17 (01) : 77 - 87
[26] RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR (RHGM-CSF) GIVEN AS DAILY SHORT INFUSIONS - A PHASE-I DOSE-TOXICITY STUDY
STEWARD, WP
SCARFFE, JH
AUSTIN, R
BONNEM, E
THATCHER, N
MORGENSTERN, G
CROWTHER, D
[J]. BRITISH JOURNAL OF CANCER, 1989, 59 (01) : 142 - 145
[27] THOMASSEN MJ, 1991, CANCER RES, V51, P857
[28] SUBCUTANEOUS GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PATIENTS WITH MYELODYSPLASTIC SYNDROME - TOXICITY, PHARMACOKINETICS, AND HEMATOLOGICAL EFFECTS
THOMPSON, JA
LEE, DJ
KIDD, P
RUBIN, E
KAUFMANN, J
BONNEM, EM
FEFER, A
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (05) : 629 - 637
[29] TREATMENT WITH GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR AND THE ADULT RESPIRATORY-DISTRESS SYNDROME
VERHOEF, G
BOOGAERTS, M
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 1991, 36 (04) : 285 - 287
[30] COLONY-STIMULATING FACTORS AND HOST DEFENSE
WEISBART, RH
GASSON, JC
GOLDE, DW
[J]. ANNALS OF INTERNAL MEDICINE, 1989, 110 (04) : 297 - 303

← 1 2 3 4 →