POTENTIAL PATHOGENICITY FOR RODENTS OF VACCINES INTENDED FOR ORAL VACCINATION AGAINST RABIES - A COMPARISON

被引:59
作者
ARTOIS, M
GUITTRE, C
THOMAS, I
LEBLOIS, H
BROCHIER, B
BARRAT, J
机构
[1] STATE UNIV LIEGE,FAC VET MED,DEPT VIROL & IMMUNOL,B-1070 BRUSSELS,BELGIUM
[2] CNRS,GENET VIRUS LAB,F-91190 GIF SUR YVETTE,FRANCE
关键词
RABIES; ORAL VACCINATION; PATHOGENICITY; RODENTS;
D O I
10.1016/0264-410X(92)90351-J
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Different oral vaccines intended to control fox rabies were administered to 271 wild rodents. Vaccines were administered orally or by the mucosal route to four different European species belonging to the genera Apodemus, Arvicola, Clethrionomys and Microtus. These rodents are likely to consume baits and to have contact with the vaccine. Two genetically engineered vaccines were tested: SAG1 (an avirulent mutant of the rabies virus) and V-RG (vaccinia recombinant virus expressing the rabies glycoprotein gene). Both were found to be completely innocuous when administered orally or by the mucosal route. The residual pathogenicity of conventional modified live vaccines derived from the SAD strain was confirmed.
引用
收藏
页码:524 / 528
页数:5
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