C-TYPE NATRIURETIC PEPTIDE IN BOVINE CHROMAFFIN CELLS - THE REGULATION OF ITS BIOSYNTHESIS AND SECRETION

被引：19
作者：
BABINSKI, K
FETHIERE, J
ROY, M
DELEAN, A
ONG, H
机构：
[1] UNIV MONTREAL,FAC PHARM,POB 6128,MONTREAL H3C 3J7,QUEBEC,CANADA
[2] UNIV MONTREAL,FAC MED,DEPT PHARMACOL,MONTREAL H3C 3J7,QUEBEC,CANADA
来源：
FEBS LETTERS | 1992年 / 313卷 / 03期
关键词：
NATRIURETIC PEPTIDE; CHROMAFFIN CELL;
D O I：
10.1016/0014-5793(92)81214-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report here the regulation of the biosynthesis and the secretion of C-type natriuretic peptide (CNP) in cultured bovine chromaffin cells. The combined treatment with protein kinase A and -C activators induced a 6-fold increase of intracellular levels of CNP-(1-103). The biosynthesized CNP-(1-103) was co-released with its mature forms, typically CNP-(51-103), upon stimulation by nicotine or depolarizing agents. This confirms the neuropeptidic character of this third member of the natriuretic peptide family, which might act as a neuromodulator or neurotransmitter.
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页码：300 / 302
页数：3
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