NEW CLASS-II-LIKE GENES IN THE MURINE MHC

被引：119

作者：

CHO, SG

ATTAYA, M

MONACO, JJ

机构：

[1] Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

NATURE | 1991年 / 353卷 / 6344期

关键词：

D O I：

10.1038/353573a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MAJOR histocompatibility complex (MHC) class I molecules present endogenous antigens to CD8+ (cytotoxic) T cells. MHC class II molecules present primarily exogenously derived antigens to CD4+ T cells. Three new genes (Ma, Mb1 and Mb2) located between the Pb and Ob genes of the murine MHC have properties indicating that they are members of the MHC class II gene family, but they are the most divergent class II members so far identified and are almost as closely related in sequence to class I genes as they are to the known class II genes.

引用

页码：573 / 576

页数：4

共 23 条

[1] STRUCTURE AND FUNCTION OF CONSTANT REGIONS OF IMMUNOGLOBULINS [J].

BEALE, D ;

FEINSTEIN, A .

QUARTERLY REVIEWS OF BIOPHYSICS, 1976, 9 (02) :135-&

[2] THE MOUSE E-BETA-2 GENE - A CLASS-II MHC BETA-GENE WITH LIMITED INTRASPECIES POLYMORPHISM AND AN UNUSUAL PATTERN OF TRANSCRIPTION [J].

BRAUNSTEIN, NS ;

GERMAIN, RN .

EMBO JOURNAL, 1986, 5 (10) :2469-2476

[3] A CLUSTER OF TRANSCRIBED SEQUENCES BETWEEN THE PB AND OB GENES OF THE MURINE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

CHO, SG ;

ATTAYA, M ;

BROWN, MG ;

MONACO, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5197-5201

[4] The beta-Chains of DP4 Molecules from Different Haplotypes Are Encoded by the Same Gene [J].

Compagnone-Post, Patricia ;

Turco, Emilia ;

Robinson, Craig ;

Trucco, Massimo .

GENOMICS, 1988, 2 (01) :8-13

[5]

COSGROVE D, IN PRESS CELL

[6] STRUCTURE AND NUCLEOTIDE-SEQUENCE OF THE HEAVY-CHAIN GENE OF HLA-DR [J].

DAS, HK ;

LAWRANCE, SK ;

WEISSMAN, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12) :3543-3547

[7] GENES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX OF THE MOUSE [J].

HOOD, L ;

STEINMETZ, M ;

MALISSEN, B .

ANNUAL REVIEW OF IMMUNOLOGY, 1983, 1 :529-568

[8]

JONSSON AK, 1987, J BIOL CHEM, V262, P8767

[9] A NEW HUMAN HLA CLASS-II-RELATED LOCUS, DM [J].

KELLY, AP ;

MONACO, JJ ;

CHO, SG ;

TROWSDALE, J .

NATURE, 1991, 353 (6344) :571-573

[10]

LARHAMMAR D, 1985, J BIOL CHEM, V260, P4111

← 1 2 3 →