TREATMENT OF DENERVATION DISUSE OSTEOPOROSIS IN THE RAT WITH A CAPACITIVELY COUPLED ELECTRICAL SIGNAL - EFFECTS ON BONE-FORMATION AND BONE-RESORPTION

被引：45

作者：

BRIGHTON, CT ^{[1
]}

TADDUNI, GT ^{[1
]}

GOLL, SR ^{[1
]}

POLLACK, SR ^{[1
]}

机构：

[1] UNIV PENN,DEPT BIOENGN,PHILADELPHIA,PA 19104

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1988年 / 6卷 / 05期

关键词：

Bone Formation - Bone Resorption - Denervation/Disuse Osteoporosis - Rat;

D O I：

10.1002/jor.1100060509

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Utilizing a sciatic neurectomy model of disuse osteoporosis, the effects on rates of bone formation and bone resorption were examined when a capacitively coupled electrical signal was applied to the denervated tibia in the rat. A low-voltage, symmetrical sine wave, 60-kHz, capacitively coupled signal had no significant effect on the amount of bone resorption occurring in denervated right tibiae in rats previously labeled with [3H]tetracycline. If a similar capacitively coupled signal was applied to rats in which osteoporosis was well established, and the rats were labeled with [3H]tetracycline daily during a 12-day treatment period, it was found that there was statistically significant enhancement of the amount of new bone formation, in the tibiae that received the signal as compared with that of the controls. Additional study results are discussed.

引用

页码：676 / 684

页数：9

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