SOMATIC MUTATIONS IN THE BRAIN - RELATIONSHIP TO AGING

被引：34

作者：

EVANS, DAP ^{[1
]}

BURBACH, JPH ^{[1
]}

VANLEEUWEN, FW ^{[1
]}

机构：

[1] UNIV UTRECHT, RUDOLF MAGNUS INST NEUROSCI,DEPT MED PHARMACOL, 3584 CG UTRECHT, NETHERLANDS

来源：

MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING | 1995年 / 338卷 / 1-6期

关键词：

BRAIN; NEURON; SOMATIC MUTATION; RECOMBINATION; DNA DAMAGE; DNA REPAIR; VASOPRESSIN;

D O I：

10.1016/0921-8734(95)00022-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic instability is generally thought to underlie the process of aging and is predominantly associated with meiosis and mitosis. This review will discuss DNA damage and repair, somatic mutations and somatic recombination events in non-dividing neurons in relation to aging. In general it can be concluded that mutagenesis operates at high frequency in the brain. Present data do not provide clear evidence for accumulating DNA damage or a change in DNA repair activity in the brain with age. However, a linear age-related increase in frameshift mutations has been shown to occur in vasopressin neurons of the rat, revealing a novel post-mitotic mechanism.

引用

页码：173 / 182

页数：10

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